Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
18
datasets available to search
ShareScore release 0.9.0
Dataset results
18 results for “succinate dehydrogenase”
Pyruvate transamination and NAD biosynthesis enable proliferation of succinate dehydrogenase-deficient cells by supporting aerobic glycolysis
<p>Data supporting results published by Ricci et al. Pyruvate transamination and NAD biosynthesis enable proliferation of succinate dehydrogenase-deficient cells by supporting aerobic glycolysis. Cell Death and Disease (2023) 14:403 (https://doi.org/10.1038/s41419-023-05927-5).</p>
Global effects of deletion of the sdh genes, encoding succinate dehydrogenase, and of cobalt on protein abundance in stationary phase Salmonella enterica serovar Typhimurium.
<p>A common strategy that bacteria utilize to increase their survival under stressful conditions in their natural environments, including antibiotic treatment, is the entry into quiescence, a state of reversible cell growth arrest that offers protection against many environmental insults. Understanding quiescence is an important fundamental question, with relevance in the medical and environmental fields. Little is known about the molecular and physiological determinants that orchestrate survival during this temporary arrest of proliferation, or those that allow a rapid transition back to the proliferating state when conditions again become favorable. In the wide host-range pathogen <em>Salmonella enterica</em> serovar Typhimurium (S. Typhimurium) and other Gram-negative bacteria, this temporary arrest of proliferation induces the expression of the alternative sigma subunit of RNA polymerase, σS/RpoS, which remodels global gene expression to reshape the cell physiology and ensure survival under starvation and various stress conditions (<em>i.e</em>., the general stress response). One important aspect of persistence is the phenotypic differentiation of quiescent populations into sub-population(s) of "persisters" that survive in the presence of lethal concentrations of antibiotics. This phenomenon is worsening the worldwide antibiotic crisis, by causing therapy failure and chronic infections and potentially favoring the development of antibiotic resistance. Understanding mechanisms governing bacterial persisters is thus an important topic and a key issue for drug developments. However, despites many studies, the physiological and molecular mechanisms controlling the formation of persisters are poorly understood and controversial.</p> <p>We have recently discovered an unexpected functional interaction between σS and succinate dehydrogenase (Sdh) in the formation of persisters. Succinate dehydrogenase (Sdh), a membrane bound complex that connects the TCA cycle and respiratory chain, is one major target down regulated by σS (Levi-Meyrueis <em>et al</em>. 2014, 2015, Lago <em>et al.</em> 2017). Stationary-phase <em>Salmonella</em> grown in LB rich medium form persisters with a higher frequency than actively growing bacteria, after transfer to fresh LB medium in the presence of lethal concentrations of ampicillin and ciprofloxacin, but not significant effect of the Δ<em>rpoS</em> mutation on this phenomenon was observed. Surprisingly however, the Δ<em>rpoS</em> mutation suppressed the defect in persister formation of a Δ<em>sdh </em>mutant. It is very likely that the Δ<em>rpoS</em> mutation compensates for a metabolic perturbation provoked by the Δ<em>sdh </em>mutation, and key for persister formation.</p> <p>To get further insights into the synthetic rescue process involved in persisters formation, we used a mass spectrometry-based proteomics approach to compare the proteome of the wild-type, Δ<em>rpoS</em>, Δ<em>sdh</em> and Δ<em>sdh</em>Δ<em>rpoS</em> strains grown to late stationary phase in nutrient-rich LB medium. Cells were also grown in LB supplemented with cobalt to pinpoint major changes induced by cobalt on the <em>Salmonella</em> proteome. Indeed, the synthetic rescue process involved in persisters formation in the presence of ampicillin was abolished when the inoculum has been grown in the presence of a non-lethal dose of cobalt (100 μM).</p> <p><strong>Accession number</strong>.The mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium via the PRIDE partner repository with the dataset identifier <strong>PXD043726.</strong></p> <p><strong>See also:</strong></p> <p>NOREL, F., & MONTEIL, V. (2023). Unraveling a synthetic rescue process involved in persisters formation [Data set]. Zenodo. https://doi.org/10.5281/zenodo.10277562</p> <p>Phégnon, L., Uttenweiler-Joseph, S., & Létisse, F. (2024). <span>Key physiological and metabolic characteristics for the differentiation of quiescent Salmonella's cells into persisters [Data set]. </span>Zenodo. <a href="https://doi.org/10.5281/zenodo.10885905" target="_blank" rel="noopener">https://doi.org/10.5281/zenodo.10885905</a></p> <p><strong>This work was supported by the French National Research Agency (ANR-19-CE44-0005-01, PERIOMET project).</strong></p> <p><strong>References</strong></p> <p>Levi-Meyrueis C, Monteil V, Sismeiro O, Dillies MA, Monot M, Jagla B<em>, et al. </em>Expanding the RpoS/sigmaS-network by RNA sequencing and identification of sigmaS-controlled small RNAs in <em>Salmonella</em>. PloS one. 2014;9(5):e96918.</p> <p>Levi-Meyrueis C, Monteil V, Sismeiro O, Dillies M-A, Kolb A, Monot M <em>et al</em>. Repressor activity of the RpoS/sigmaS-dependent RNA polymerase requires DNA binding. Nucleic Acids Res 2015 43, 1456–1468.</p> <p>Lago M, Monteil V, Douche T, Guglielmini J, Criscuolo A, Maufrais C, <em>et al</em>. Proteome remodelling by the stress sigma factor RpoS/sigma(S) in <em>Salmonella</em>: identification of small proteins and evidence for post-transcriptional regulation. Scientific reports. 2017;7(1):2127.</p> <p> </p>
A Phase II Trial of the DNA Methyl Transferase Inhibitor, Guadecitabine (SGI-110), in Children and Adults With Wild Type GIST,Pheochromocytoma and Paraganglioma Associated With Succinate Dehydrogenase
ClinicalTrials.gov study NCT03165721. IPD Sharing: NO. Countries: 1. Publications: 1.
Phase 2 Clinical Trial of SGS-742 Therapy in Succinic Semialdehyde Dehydrogenase Deficiency
ClinicalTrials.gov study NCT02019667. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Itaconate drives mtRNA-mediated Type I interferon production via inhibition of succinate dehydrogenase
Open the record for dataset details and reuse information.
Relationship Between Succinate Dehydrogenase Mutations and High-Altitude Illness
ClinicalTrials.gov study NCT00202683. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Natural History Study of Patients With Succinic Semialdehyde Dehydrogenase (SSADH) Deficiency
ClinicalTrials.gov study NCT03758521. IPD Sharing: Not stated. Countries: 4. Publications: 2.
Brain Excitability in Patients With Succinic Semialdehyde Dehydrogenase Deficiency
ClinicalTrials.gov study NCT00132366. IPD Sharing: Not stated. Countries: 1. Publications: 3.
PET Imaging of GABA Receptors in Succinic Semialdehyde Dehydrogenase Deficiency
ClinicalTrials.gov study NCT00246870. IPD Sharing: Not stated. Countries: 1. Publications: 3.
One deficiency, different outcomes: Succinate dehydrogenase loss in chromaffin cell vs. fibroblast models of paraganglioma
GEO Series GSE263778. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Succinate Dehydrogenase Regulates Homeostasis and Metabolic Integrity of Alveolar Macrophages
GEO Series GSE288614. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Temozolomide (TMZ) in Advanced Succinate Dehydrogenase (SDH)-Mutant/Deficient Gastrointestinal Stromal Tumor (GIST)
ClinicalTrials.gov study NCT03556384. IPD Sharing: NO. Countries: 1. Publications: 0.
Succinate dehydrogenase deficiency-driven succinate accumulation induces drug resistance in acute myeloid leukemia via ubiquitin-cullin regulation
GEO Series GSE247623. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Succinate dehydrogenase (SDH)-Complex II regulates skeletal muscle cellular respiration and fatigue but not muscle mass in genetically induced pulmonary emphysema [20 wk]
GEO Series GSE255635. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Succinate dehydrogenase (SDH)-Complex II regulates skeletal muscle cellular respiration and fatigue but not muscle mass in genetically induced pulmonary emphysema [3 wk]
GEO Series GSE255632. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Global transcriptional response of Saccharomyces cerevisiae following the deletion of succinate dehydrogenase
GEO Series GSE13924. Saccharomyces cerevisiae. 2 samples. Type: Expression profiling by array.
Characterizing gene expression changes that accompany succinate dehydrogenase subunit B (SDHB) RNA editing in monocyte-enriched peripheral blood mononuclear cell cultures
GEO Series GSE45900. Homo sapiens. 12 samples. Type: Expression profiling by array.
Itaconate links inhibition of succinate dehydrogenase with macrophage metabolic remodeling and regulation of inflammation
GEO Series GSE82043. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.