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169 results for “sustained release”
A floating 3D printed formulation for the coadministration and sustained release of antihypertensive drugs - Underlying CT data
<p>Underlying CT data of <strong>"A floating 3D printed formulation for the coadministration and sustained release of antihypertensive drugs"</strong></p> <p>Paola Zgouro1, Orestis L. Katsamenis3,4, Thomas Moschakis5, Georgios K. Eleftheriadis6, Athanasios S. Kyriakidis6, Konstantina Chachlioutaki1,2, Paraskevi Kyriaki Monou1,2, Marianna Ntorkou7, Constantinos K. Zacharis7, Nikolaos Bouropoulos8,9, Dimitrios G. Fatouros1,2, Christina Karavasili1, Christos I. Gioumouxouzis1</p> <p><em>1 Laboratory of Pharmaceutical Technology, Department of Pharmaceutical Sciences, Aristotle University of Thessaloniki, GR-54124, Thessaloniki, Greece</em><br><em>2 Center for Interdisciplinary Research and Innovation (CIRI-AUTH), 57001 Thessaloniki, Greece</em><br><em>3 μ-VIS X-Ray Imaging Centre, Faculty of Engineering and Physical Sciences, University of Southampton, Southampton, SO17 1BJ, UK</em><br><em>4 Institute for Life Sciences, University of Southampton, University Rd, Highfield, Southampton, SO17 1BJ, UK</em><br><em>5 Department of Food Science and Technology, School of Agriculture, Aristotle University of Thessaloniki, GR-541 24 Thessaloniki, Greece</em><br><em>6 Pharmacare Premium Limited, R&D Department, HHF003 Hal Far Industrial Estate, Birzebbugia BBG3000, Malta</em><br><em>7 Laboratory of Pharmaceutical Analysis, Department of Pharmacy, Aristotle University of Thessaloniki, GR-54124, Greece</em><br><em>8 Department of Materials Science, University of Patras, 26504 Rio, Patras, Greece</em><br><em>9 Foundation for Research and Technology Hellas, Institute of Chemical Engineering and High Temperature Chemical Processes, Patras, Greece</em></p> <p><strong>Microfocus Computed Tomography (μCT)</strong></p> <p>X-ray microfocus computed tomography (μCT) was employed for the characterization of the microstructure of the printed object, assessing the overall volume, porosity, local thickness and other printing defects. The imaging took place at the University of Southampton’s μ-VIS X-ray Imaging Centre (<a title="&mu;-VIS X-ray Imaging Centre at the University of Southampton" href="https://www.muvis.org" target="_blank" rel="noopener">www.muvis.org</a>) / 3D X-ray Histology facility using a customized μCT scanner optimized for 3D X-ray histology (<a title="3D X-ray Histology facility at University of Southampton" href="https://www.xrayhistology.org" target="_blank" rel="noopener">www.xrayhistology.org</a>) (<a title="A high-throughput 3D X-ray histology facility for biomedical research and preclinical applications" href="https://doi.org/10.12688/wellcomeopenres.19666.2" target="_blank" rel="noopener">Katsamenis et al., 2023</a>) based on Nikon’s XTH225ST system (Nikon Metrology, Castle Donington, UK). The scanner was operated at 110 kVp / 90 μA (9.9 W), with the X-ray beam prefiltered using 0.04 mm of aluminum. The source-to-object and source-to-detector distances were 28.4 mm and 1136.7 mm, respectively, resulting in a magnification factor of 40x. Acquisition parameters included 2201 projections, averaging 4 frames per projection, with an exposure time of 177 ms per projection. The 2850 x 2850 dexels detector was binned 2x (virtual detector: 1425 × 1425 dexels), resulting in an isotropic voxel edge of 7.5 μm. The reconstructed data underwent visualization and analysis using Dragonfly software (Comet Technologies Canada Inc.; software available at http://www.theobjects.com/dragonfly).</p>
Fig. 1 in The red imported fire ant (Hymenoptera: Formicidae) in the West Indies: distribution of natural enemies and a possible test bed for release of self-sustaining biocontrol agents
Fig. 1. Distribution of 2 fire ant microsporidian pathogens (Kneallhazia solenopsae, Vairimorpha invictae) and 2 fire ant viruses (SINV-1, SiDNV) among collections of the red imported fire ant, Solenopsis invicta, from islands in the West Indies. The fire ant RNA viruses SINV-2 and SINV-3 were not detected in any of the collections. The number of collections from monogyne colonies is shown over the total number of collections for each island or island group (Tortola [1/5], St. John [0/1], and St. Thomas [3/4]).
Study Evaluating Desvenlafaxine Succinate Sustained Release (DVS SR) in the Treatment of Major Depressive Disorder
ClinicalTrials.gov study NCT00798707. IPD Sharing: Not stated. Countries: 2. Publications: 6.
Efficacy and Safety Study of Bimatoprost Sustained-Release (SR) in Participants With Open-angle Glaucoma or Ocular Hypertension
ClinicalTrials.gov study NCT02247804. IPD Sharing: Not stated. Countries: 14. Publications: 2.
Comparison of Bimatoprost Sustained Release (SR) to Selective Laser Trabeculoplasty (SLT) in Adults With Open-Angle Glaucoma or Ocular Hypertension
ClinicalTrials.gov study NCT02507687. IPD Sharing: YES. Countries: 12. Publications: 2.
Study Evaluating Desvenlafaxine Succinate Sustained Release (DVS SR) vs. Escitalopram in Postmenopausal Women
ClinicalTrials.gov study NCT00406640. IPD Sharing: Not stated. Countries: 6. Publications: 1.
Open-Label Drug Interaction Study Evaluating Desvenlafaxine Succinate Sustained Release (DVS SR) 100mg On The Pharmacokinetics Of Tamoxifen When Coadministered To Healthy Post-Menopausal Female Subjec
ClinicalTrials.gov study NCT01189500. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Study Evaluating Desvenlafaxine Succinate Sustained Release (DVS SR) In The Treatment Of Major Depressive Disorder
ClinicalTrials.gov study NCT00384033. IPD Sharing: Not stated. Countries: 1. Publications: 7.
Efficacy and Safety of Bimatoprost Sustained-Release (SR) in Patients With Open-Angle Glaucoma or Ocular Hypertension
ClinicalTrials.gov study NCT02250651. IPD Sharing: Not stated. Countries: 15. Publications: 3.
Study Evaluating Desvenlafaxine Succinate Sustained Release In Adults With Major Depressive Disorder
ClinicalTrials.gov study NCT00863798. IPD Sharing: Not stated. Countries: 1. Publications: 7.
Study Evaluating Desvenlafaxine Succinate Sustained-Release (DVS SR) in Adult Outpatients With Major Depressive Disorder (MDD)
ClinicalTrials.gov study NCT01432457. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Study Evaluating Desvenlafaxine Succinate Sustained-Release (DVS SR) In The Treatment Of Peri- And Postmenopausal Women With Major Depressive Disorder (DVS 3364)
ClinicalTrials.gov study NCT01121484. IPD Sharing: Not stated. Countries: 1. Publications: 8.
A Trial to Evaluate the Efficacy, Safety, and Tolerability of Centanafadine Sustained-release Tablets in Adults With Attention-deficit/Hyperactivity Disorder
ClinicalTrials.gov study NCT03605836. IPD Sharing: YES. Countries: 1. Publications: 1.
Comparison of 23 mg Donepezil Sustained Release (SR) to 10 mg Donepezil Immediate Release (IR) in Patients With Moderate to Severe Alzheimer's Disease
ClinicalTrials.gov study NCT00478205. IPD Sharing: Not stated. Countries: 1. Publications: 6.
Relapse Prevention Study Of Desvenlafaxine Succinate Sustained Release In Outpatients With Major Depressive Disorder
ClinicalTrials.gov study NCT00887224. IPD Sharing: Not stated. Countries: 14. Publications: 5.
A Study of the Effectiveness and Safety of Sustained-release Hydromorphone (a Strong Opioid) in Patients With Chronic Noncancer Pain.
ClinicalTrials.gov study NCT00261495. IPD Sharing: Not stated. Countries: 10. Publications: 1.
Study Evaluating Desvenlafaxine Succinate Sustained-release (DVS SR) in Adult Outpatients With Pain Associated With Diabetic Peripheral Neuropathy
ClinicalTrials.gov study NCT00283842. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Method-of-Use Study Assessing the Effect of Naltrexone Sustained Release (SR)/ Bupropion SR on Body Weight and Cardiovascular Risk Factors in Overweight and Obese Subjects
ClinicalTrials.gov study NCT01764386. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Study Evaluating Desvenlafaxine Succinate Sustained Release (DVS SR) Versus Placebo in Peri- and Postmenopausal Women
ClinicalTrials.gov study NCT00369343. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Resveratrol loaded chitosan-pectin core-shell nanoparticles as novel drug delivery vehicle for sustained release and improved antioxidant activities
<p><span>Resveratrol, chemically known as 3, 5, 4'-trihydroxy-trans-stilbene, is a natural polyphenol with promising multi-targeted health benefits. The optimal therapeutic uses of resveratrol are limited due to its poor solubility, rapid metabolism and low bioavailability. To address the issues, we have encapsulated resveratrol inside the nanosized core made of chitosan and coated this core with pectin - shell in order to fabricate a drug delivery vehicle which can entrap resveratrol for a longer period of time. The core - shell nanoparticles fabricated in this way were characterized with the help of Fourier Transform Infrared Spectrometer (FTIR), Field Emission Scanning Electron Microscope (FESEM), Field Emission Transmission electron microscopy/Selected Area Electron Diffraction (FETEM/SAED), High-Resolution Transmission Electron Microscope (HRTEM)), Dynamic Light Scattering (DLS) and Zeta Potential measurements. In vitro drug release study showed the ability of the core-shell nanoparticles to provide sustained release of resveratrol for almost 30 hours. The release efficiency of the drug was found to be pH dependent and a sequential control over drug release can be obtained varying the shell thickness. The resveratrol encapsulated in a nanocarrier was found to have a better in vitro antioxidant activity than free resveratrol as determined by DPPH radical scavenging method. This work finally offers a novel nano-based drug delivery system.</span></p>
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International Brain Laboratory public data
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OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.