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32 results for “synaptic transmission”
Silencing of hippocampal synaptic transmission impairs spatial reward search on a head-fixed tactile treadmill task
<p>Publication data</p> <p>This repository contains the raw data files for the following manuscript:</p> <p>Title: Silencing of hippocampal synaptic transmission impairs spatial reward search on a head-fixed tactile treadmill task<br> Authors: Jake T. Jordan and J. Tiago Gonçalves<br> Pre-print in bioRxiv. doi:10.1101/2021.09.03.458092 (2021)</p> <p>A summary of all experimental groups and data tables and included as two Excel (.xlsx) files: DREADDs_Cued.xlsl and DREADDs_Spatial.xlsl, these correspond to figures 2 and 3 of the publication, respectively.</p> <p>The raw data files were acquired as described in Jordan et al. (2021a) doi:10.1016/j.xpro.2021.100770 <br> Software code for data acquisition and interpretation is available at doi:10.5281/zenodo.5196612</p>
The amyloid precursor protein regulates synaptic transmission at medial perforant path synapses
<p><span>The perforant path provides the primary cortical excitatory input to the hippocampus. Due to its important role in information processing and coding, entorhinal projections to the dentate gyrus have been studied in considerable detail. Nevertheless, synaptic transmission between individual connected pairs of entorhinal </span><span>stellate cells and dentate granule cells</span><span> remains to be characterized. Here, we have used mouse organotypic entorhino-hippocampal tissue cultures of either sex, in which the entorhino-dentate (EC-GC) projection is present and EC-GC pairs can be studied using whole-cell patch clamp recordings. By using cultures of wildtype mice, the properties of EC-GC synapses formed by afferents from the lateral and medial entorhinal cortex were compared and differences in short-term plasticity were identified. Since the perforant path is severely affected in Alzheimer´s disease, we used tissue cultures of amyloid-precursor protein (APP)-deficient mice to examine the role of APP at this synapse. APP deficiency altered excitatory neurotransmission at medial perforant path synapses, which was accompanied by transcriptomic and ultrastructural changes. Moreover, presynaptic but not postsynaptic APP deletion through the local injection of Cre-expressing adeno-associated viruses in conditional APP<sup>flox/flox</sup> tissue cultures increased the neurotransmission efficacy at perforant path synapses. In summary, these data suggest a physiological role for presynaptic APP at medial perforant path synapses that may be adversely affected under altered APP processing conditions.</span></p>
Differential Short-Term Facilitation Of Synaptic Inputs And Spike Transmission At The Retinocollicular Synapse In Vivo
<p>Neuropixels data for investigating short-term plasticity in the mouse retinocollicular pathway. </p> <p>Paper (bioRxiv): <a href="https://www.biorxiv.org/content/10.1101/2024.01.17.576068v1">Differential Short-Term Facilitation Of Synaptic Inputs And Spike Transmission At The Retinocollicular Synapse In Vivo</a></p> <p>Full data will be availale upon publication of the paper.</p>
Data from: Dopamine and serotonin co-transmission filters striatonigral synaptic activity via 5-HT1B receptor activation
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The amyloid precursor protein regulates synaptic transmission at medial perforant path synapses
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A scaffold attachment factor PHM-2 regulates synaptic transmission through SLO-2 potassium channel in C. elegans
GEO Series GSE315272. Caenorhabditis elegans. 6 samples. Type: Expression profiling by high throughput sequencing.
The outer retina in young P23H retinitis pigmentosa mice overexpresses critical components of synaptic transmission
GEO Series GSE291972. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Monozygotic twins discordant for schizophrenia differ in maturation and synaptic transmission
GEO Series GSE263672. Homo sapiens. 14 samples. Type: Expression profiling by high throughput sequencing.
Expression of the neuronal tRNA n-Tr20 regulates synaptic transmission and seizure susceptibility
GEO Series GSE151742. Mus musculus. 33 samples. Type: Expression profiling by high throughput sequencing; Other.
Stress-induced translation of KCNB1 contributes to the enhanced synaptic transmission of the lateral habenula
GEO Series GSE249051. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing; Other.
Bipolar and schizophrenia risk gene AKAP11 encodes an autophagy receptor coupling the regulation of PKA kinase network homeostasis to synaptic transmission
GEO Series GSE304457. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Gain of bipolar disorder-related lncRNA AP1AR-DT in mice induces depressive and anxiety-like behaviors by reducing Negr1-mediated excitatory synaptic transmission [Mouse RNA-seq]
GEO Series GSE272753. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Gain of bipolar disorder-related lncRNA AP1AR-DT in mice induces depressive and anxiety-like behaviors by reducing Negr1-mediated excitatory synaptic transmission [SK-N-SH RNA-seq]
GEO Series GSE272752. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Paraventricular hypothalamic RUVBL2 neurons suppress appetite by enhancing excitatory synaptic transmission in distinct neurocircuits [RNA-seq]
GEO Series GSE252308. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Synaptic-like transmission between neural axons and arterial smooth muscle cells drives cerebral neurovascular coupling
GEO Series GSE213026. Mus musculus. 17 samples. Type: Expression profiling by high throughput sequencing.
Remodeling of synaptic transmission genomic fabrics in the hypothalamic arcuate nucleus of a rat female model of infantile spasms
GEO Series GSE84585. Rattus norvegicus. 20 samples. Type: Expression profiling by array.
Impaired inhibitory GABAergic synaptic transmission and transcription studied in single neurons by Patch-seq in Huntington’s disease
GEO Series GSE171099. Mus musculus. 127 samples. Type: Expression profiling by high throughput sequencing.
Paraventricular hypothalamic RUVBL2 neurons suppress appetite by enhancing excitatory synaptic transmission in distinct neurocircuits
GEO Series GSE249791. Mus musculus. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Remodeling of synaptic transmission genomic fabrics in a model of infantile spasms
GEO Series GSE81061. Rattus norvegicus. 20 samples. Type: Expression profiling by array.
The amyloid precursor protein regulates synaptic transmission at medial perforant path synapses
GEO Series GSE213284. Mus musculus. 14 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.