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36 results for “toxic risk”
Verzehrsstudie zur Ermittlung der Lebensmittelaufnahme von Säuglingen und Kleinkindern für die Abschätzung eines akuten Toxizitätsrisikos durch Rückstände von Pflanzenschutzmitteln (VELS) [Consumption study to determine the food intake of infants and young children for the estimation of an acute toxicity risk through residues of plant protection products]
<p>The VELS study (<strong>V</strong>erzehrsstudie zur <strong>E</strong>rmittlung der Lebensmittelaufnahme von <strong>S</strong>äuglingen und Kleinkindern für die Abschätzung eines akuten Toxizitätsrisikos durch Rückstände von Pflanzenschutzmitteln; VELS) was conducted in 2001/2002. Data were collected from 804 infants, toddlers and children (age group 0.5 to <5 years) in Germany. The food consumed was recorded by the parents as "food as eaten" over a total of 6 days (2x3-day food record with an interval of 3-6 months for toddlers and 4-8 weeks for infants). Anthropometric data are also included.</p> <p>Foods are coded according to the German food coding system (BLS; Bundeslebensmittelschlüssel) and food names and additional information is available in German only.</p> <p>Dataset owner: German Federal Institute for Risk Assessment (BfR)</p> <p>Data collection was carried out by the University of Paderborn on behalf of the Federal Ministry of Food and Agriculture [Bundesministerium für Ernährung und Landwirtschaft; BMEL] – formerly Federal Ministry for Food, Agriculture and Consumer Protection [Bundesministerium für Verbraucherschutz, Ernährung und Landwirtschaft; BMVEL]</p>
Data from: Larger frogs are better mimics but are more risk-averse in a non-toxic poison frog
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An advancement in developmental and reproductive toxicity (DART) risk assessment: evaluation of a bioactivity and exposure-based NAM toolbox
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Identifying in vitro toxicity testing approaches for (novel) proteins in the context of food and feed risk assessment
<p>Annexes to EFSA external scientific report Identifying <em>in vitro</em> toxicity testing approaches for (novel) proteins in the context of food and feed risk assessment</p>
Trial Comparing Prone and Supine Intensity-modulated Radiotherapy (IMRT) After Breast-conserving Surgery in Patients With Large Breast Volume at High Risk for Skin Toxicity and Fibrosis
ClinicalTrials.gov study NCT00887523. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Cardiovascular Morbidity in Testicular Cancer Survivors: Study of Risk Factors and Assessment of Pharmacogenomic Determinants of Toxicity
ClinicalTrials.gov study NCT00161174. IPD Sharing: Not stated. Countries: 1. Publications: 52.
Study Evaluating Impact of IL-7 on CD4 Lymphopenia, Risks of Severe Haematological Toxicity and Tumor Progression in Metastatic Breast Cancer Patients
ClinicalTrials.gov study NCT01368107. IPD Sharing: Not stated. Countries: 1. Publications: 28.
JOint Use of Database to Identify Risk Factors of CARDio-vascular Toxicity Induced by Immune Checkpoint Inhibitors
ClinicalTrials.gov study NCT04294771. IPD Sharing: NO. Countries: 1. Publications: 7.
Cardiovascular Toxicity Induced by Antitumoral Drugs: Risk Assessment and Early Diagnosis. CARDIOTOX Registry
ClinicalTrials.gov study NCT02039622. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Thal-Fabs: Reduced Toxicity Conditioning for High Risk Thalassemia
ClinicalTrials.gov study NCT05426252. IPD Sharing: NO. Countries: 1. Publications: 1.
Reduced Toxicity Conditioning Prior to Unrelated Cord Cell Transplantation for High Risk Myeloid Malignancies
ClinicalTrials.gov study NCT02333838. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Clinical Trial to Assess the Efficacy and Toxicity of Induction and Consolidation With CPX-351 for Patients Aged 60 to 75 Years With Secondary or High-risk Acute Myeloid Leukemia
ClinicalTrials.gov study NCT04230239. IPD Sharing: NO. Countries: 1. Publications: 14.
Risk Factors of Immune-ChEckpoint Inhibitors MEdiated Liver, Gastrointestinal, Endocrine and Skin Toxicity
ClinicalTrials.gov study NCT04631731. IPD Sharing: UNDECIDED. Countries: 1. Publications: 4.
S1501 Dual Observational and Randomized Cohort Study of Patients With Metastatic HER-2+ Breast Cancer at Risk of Cardiac Toxicity
ClinicalTrials.gov study NCT03418961. IPD Sharing: Not stated. Countries: 4. Publications: 1.
Advancing systemic toxicity risk assessment: Evaluation of a NAM-based toolbox approach
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Data from: Identification of candidate risk factor genes for human idelalisib toxicity using a collaborative cross approach
Idelalisib is a phosphatidylinositol 3-kinase inhibitor highly selective for the delta isoform that has shown good efficacy in treating chronic lymphocytic leukemia and follicular lymphoma. In clinical trials, however, idelalisib was associated with rare, but potentially serious liver and lung toxicities. In this study, we used the Collaborative Cross (CC) mouse population to identify genetic factors associated with the drug response that may inform risk management strategies for idelalisib in humans. Eight (8) male mice (4 matched pairs) from 50 CC lines were treated once daily for 14 days by oral gavage with either vehicle or idelalisib at a dose selected to achieve clinically-relevant peak plasma concentrations (150 mg/kg/day). The drug was well tolerated across all CC lines, and there were no observations of overt liver injury. Differences across CC lines were seen in drug concentration in plasma samples collected at the approximate Tmax on study Days 1, 7, and 14. There were also small but statistically significant treatment-induced alterations in plasma total bile acids and microRNA-122, and these may indicate early hepatocellular stress required for immune-mediated hepatotoxicity in humans. Idelalisib treatment further induced significant elevations in the total cell count of terminal bronchoalveolar lavage fluid, which may be analogous to pneumonitis observed in the clinic. Genetic mapping identified loci associated with interim plasma idelalisib concentration and the other three treatment-related endpoints. Thirteen (13) priority candidate quantitative trait genes identified in CC mice may now guide interrogation of risk factors for adverse drug responses associated with idelalisib in humans.
EMR Chemotoxicity Risk Calculator To Decrease Chemotherapy Toxicity
ClinicalTrials.gov study NCT05809557. IPD Sharing: NO. Countries: 1. Publications: 0.
Stem Cell Transplantation To Treat High Risk Multiple Myeloma With Reduced Toxicity Myeloablative Conditioning Regimen
ClinicalTrials.gov study NCT00615589. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Wearable Technology and Machine Learning for Early Detection and Risk Assessment of Unacceptable Toxicities in a Paediatric Oncology Cohort
ClinicalTrials.gov study NCT07030998. IPD Sharing: YES. Countries: 1. Publications: 0.
Data from: Identification of candidate risk factor genes for human idelalisib toxicity using a collaborative cross approach
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Allen Brain Atlas
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OpenNeuro
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