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ShareScore release 0.9.0
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421 results for “transcriptional repression”
Data from: Suppression of Huntington’s disease somatic instability by transcriptional repression and direct CAG repeat binding
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Predictive modeling reveals that higher-order cooperativity drives transcriptional repression in a synthetic developmental enhancer
<p>A challenge in quantitative biology is to predict output patterns of gene expression from knowledge of input transcription factor patterns and from the arrangement of binding sites for these transcription factors on regulatory DNA. We tested whether widespread thermodynamic models could be used to infer parameters describing simple regulatory architectures that inform parameter-free predictions of more complex enhancers in the context of transcriptional repression by Runt in the early fruit fly embryo. By modulating the number and placement of Runt binding sites within an enhancer, and quantifying the resulting transcriptional activity using live imaging, we discovered that thermodynamic models call for higher-order cooperativity between multiple molecular players. This higher-order cooperativity capture the combinatorial complexity underlying eukaryotic transcriptional regulation and cannot be determined from simpler regulatory architectures, highlighting the challenges in reaching a predictive understanding of transcriptional regulation in eukaryotes and calling for approaches that quantitatively dissect their molecular nature.</p>
Transcriptional repression by a secondary DNA binding surface of DNA topoisomerase I safeguards against transcription overdrive
<p>Molecular dynamics simulation input files and processed output trajectories.</p>
Predictive modeling reveals that higher-order cooperativity drives transcriptional repression in a synthetic developmental enhancer
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Data from: Heterochromatin suppresses gross chromosomal rearrangements at centromeres by repressing Tfs1/TFIIS-dependent transcription
Heterochromatin that is characterized by histone H3 lysine 9 (H3K9) methylation assembles on repetitive regions including centromeres. Although centromeric heterochromatin is important for faithful segregation of chromosomes, its role in maintaining centromere integrity remains elusive. Here, we found in fission yeast that heterochromatin suppresses gross chromosomal rearrangements (GCRs) at centromeres. Mutations in Clr4/Suv39 methyltransferase increased the formation of isochromosomes whose breakpoints are present in centromere repeats. H3K9A and H3K9R mutations also increased GCRs, suggesting that Clr4 appears to suppress GCRs via H3K9 methylation. Both HP1 homologs, Swi6 and Chp2, and an RNAi component Chp1 were the chromodomain proteins that are essential for full suppression of GCRs. Remarkably, mutations in RNA polymerase II (RNAPII) or the transcription factors including Tfs1/TFIIS which facilitates restart of backtracked RNAPII specifically bypassed the requirement of Clr4 to suppress GCRs. These results demonstrate that heterochromatin suppresses GCRs by repressing Tfs1-dependent transcription of centromere repeats.
Data from: Heterochromatin suppresses gross chromosomal rearrangements at centromeres by repressing Tfs1/TFIIS-dependent transcription
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SS18::SSX redistributes BAF chromatin remodelers selectively to activate and repress transcription [ChIP-Seq, Hi-ChIP]
GEO Series GSE269770. Mus musculus. 71 samples. Type: Other.
The transcription factor Gli3 promotes B cell development in the fetal liver through repression of Shh
GEO Series GSE81467. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
DROSHA and DICER RNA products control BMI1-dependent transcriptional repression at DNA damage sites
GEO Series GSE193821. Homo sapiens. 26 samples. Type: Expression profiling by high throughput sequencing.
MeCP2 represses the rate of transcriptional initiation of highly methylated long genes (PRO-Seq)
GEO Series GSE128183. Mus musculus. 26 samples. Type: Expression profiling by high throughput sequencing; Other.
The Ess1 prolyl isomerase represses TERRA transcription and promotes telomere replication in Saccharomyces cerevisiae
GEO Series GSE308552. Saccharomyces cerevisiae. 4 samples. Type: Expression profiling by high throughput sequencing.
A Myt1 family transcription factor defines neuronal fate by repressing non-neuronal genes
GEO Series GSE125694. Caenorhabditis elegans. 8 samples. Type: Expression profiling by high throughput sequencing.
The circadian PRRs quintet orchestrates photoperiodic responsive hypocotyl growth by transcriptionally repressing PIF4/PIF5 in Arabidopsis
GEO Series GSE116381. Arabidopsis thaliana. 6 samples. Type: Expression profiling by high throughput sequencing.
Evidence that direct inhibition of transcription factor binding is the prevailing mode of gene and repeat repression by DNA methylation [RNA-Seq]
GEO Series GSE184469. Mus musculus; Homo sapiens. 40 samples. Type: Expression profiling by high throughput sequencing.
CHD4 is essential for transcriptional repression and lineage progression in B lymphopoiesis [RNA-seq]
GEO Series GSE123502. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Transcriptional Analyses of citrus host defense response repression by feeding of Diaphorina citri transmitting Candidatus Liberibacter asiaticus at early stages of infection
GEO Series GSE154151. Citrus sinensis. 17 samples. Type: Expression profiling by high throughput sequencing.
Integrated Transcriptome Profiling Revealed That Elevated Long Non- Coding RNA-AC007278.2 Expression Repressed CCR7 Transcription in Systemic Lupus Erythematosus
GEO Series GSE139350. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Nucleoporin Seh1 controls murine neocortical development via transcriptional repression of p21 in neural stem cells
GEO Series GSE205508. Mus musculus. 3 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Perturbed maintenance of transcriptional repression on the inactive X-chromosome in the mouse brain after XIST deletion
GEO Series GSE119066. Mus musculus. 13 samples. Type: Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing.
Chd1 chromatin remodelers maintain nucleosome organization and repress cryptic transcription
GEO Series GSE40872. Schizosaccharomyces pombe. 29 samples. Type: Expression profiling by array; Genome binding/occupancy profiling by array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.