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13 results for “transglutaminase 2”
Urinary Transglutaminase 2 as a Biomarker for Kidney Allograft Fibrosis
ClinicalTrials.gov study NCT03487861. IPD Sharing: Not stated. Countries: 1. Publications: 14.
Data from: Enhanced B-cell receptor recognition of the autoantigen transglutaminase 2 by efficient catalytic self-multimerization
A hallmark of the gluten-driven enteropathy celiac disease is autoantibody production towards the enzyme transglutaminase 2 (TG2) that catalyzes the formation of covalent protein-protein cross-links. Activation of TG2-specific B cells likely involves gluten-specific CD4 T cells as production of the antibodies is dependent on disease-associated HLA-DQ allotypes and dietary intake of gluten. IgA plasma cells producing TG2 antibodies with few mutations are abundant in the celiac gut lesion. These plasma cells and serum antibodies to TG2 drop rapidly after initiation of a gluten-free diet, suggestive of extrafollicular responses or germinal center reactions of short duration. High antigen avidity is known to promote such responses, and is also important for breakage of self-tolerance. We here inquired whether TG2 avidity could be a feature relevant to celiac disease. Using recombinant enzyme we show by dynamic light scattering and gel electrophoresis that TG2 efficiently utilizes itself as a substrate due to conformation-dependent homotypic association, which involves the C-terminal domains of the enzyme. This leads to the formation of covalently linked TG2 multimers. The presence of exogenous substrate such as gluten peptide does not inhibit TG2 self-cross-linking, but rather results in formation of TG2-TG2-gluten complexes. The celiac disease autoantibody epitopes, clustered in the N-terminal part of TG2, are conserved in the TG2-multimers as determined by mass spectrometry and immunoprecipitation analysis. TG2 multimers are superior to TG2 monomer in activating A20 B cells transduced with TG2-specific B-cell receptor, and uptake of TG2-TG2-gluten multimers leads to efficient activation of gluten-specific T cells. Efficient catalytic self-multimerization of TG2 and generation of multivalent TG2 antigen decorated with gluten peptides suggest a mechanism by which self-reactive B cells are activated to give abundant numbers of plasma cells in celiac disease. Importantly, high avidity of the antigen could explain why TG2-specific plasma cells show signs of an extrafollicular generation pathway.
Data from: Enhanced B-cell receptor recognition of the autoantigen transglutaminase 2 by efficient catalytic self-multimerization
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Transglutaminase 2 regulates terminal erythroid differentiation via cross-linking activity
GEO Series GSE229589. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Essential role for CD30-Transglutaminase 2 axis in memory Th1 and Th17 cell generation.
GEO Series GSE151691. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Transglutaminase 2 regulates ovarian cancer metastasis by modulating the immune microenvironment
GEO Series GSE303025. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Essential role for CD30-Transglutaminase 2 axis in memory Th1 and Th17 cell generation.
GEO Series GSE151301. Mus musculus. 4 samples. Type: Expression profiling by array.
Transglutaminase Type 2 regulates the Wnt/β-catenin pathway in vertebrates
GEO Series GSE162071. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Role of transglutaminase 2 in promoting biglycan synthesis in idiopathic gingival fibromatosis
GEO Series GSE277572. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Role of Transglutaminase 2 in Liver Injury via Crosslinking and Silencing of Transcription Factor, Sp1
GEO Series GSE10285. Mus musculus. 8 samples. Type: Expression profiling by array.
transglutaminase 2 (TGM2) and Its Novel Targeted Activator in Diabetic Bone Regeneration: From Mechanism to Application
GEO Series GSE301059. Rattus norvegicus. 6 samples. Type: Non-coding RNA profiling by array.
Transglutaminase 2 regulates vimentin-dependent proteostasis during macrophage activation in sepsis
GEO Series GSE301229. Mus musculus. 21 samples. Type: Expression profiling by high throughput sequencing.
Inhibition of transglutaminase 2 mitigates transcriptional dysregulation in models of Huntington disease
GEO Series GSE21237. Mus musculus. 23 samples. Type: Expression profiling by array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.