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219 results for “treatment selection”
Regional drinking water quality monitoring program: long-term monitoring of water quality in select canals, reservoirs, and treatment plants of the greater Phoenix, Arizona metropolitan area drinking water system, ongoing since 1998
Regional Drinking Water Quality Monitoring Program ================================================== Arizona Statue University (ASU) has been working with regional water providers (Salt River Project (SRP), Central Arizona Project (CAP)) and metropolitan Phoenix cities since 1998 on algae-related issues affecting drinking water supplies, treatment, and distribution. The results have improved the understanding of taste and odor (T&O) occurrence, control, and treatment, improved the understanding of dissolved organic and algae dynamics, and initiated a forum to discuss and address regional water quality issues. The monitoring benefits local Water Treatment Plants (WTPs) by optimizing ongoing operations (i.e., reducing operating costs), improving the quality of municipal water for consumers, facilitating long-term water quality planning, and providing information on potentially future-regulated compounds. ASU has been monitoring water quality in terminal reservoirs (Lake Pleasant, Saguaro Lake, and Bartlett Lake) continuously from 1998 to the present for algae-related constituents (taste and odors, and more recently metals from the upper reservoirs), nutrients, and disinfection by-product precursors (i.e., total and dissolved organic carbon and organic nitrogen). Additional monitoring has been conducted in the SRP and CAP canal systems and in water treatment plants in Phoenix, Tempe and Peoria. During this work the Valley has been in a prolonged drought and recently one above average wet year, and this data provides important baseline data for development of new or expanded WTPs and management of existing WTPs in the future. The current work has improved the understanding of T&O sources and treatment, but additional research and monitoring into the future is necessary. Reservoir monitoring is conducted once per month at Bartlett Lake, Saguaro Lake, and Lake Pleasant, and quarterly at Roosevelt, Apache, and Canyon Lakes. Samples are depth integrated in the epilimnion a
Data for: Weaker selection on genes with treatment-specific expression consistent with a limit on plasticity evolution in Arabidopsis thaliana
<p>Differential gene expression between environments often underlies phenotypic plasticity. However, environment-specific expression patterns are hypothesized to relax selection on genes, and thus limit plasticity evolution. We collated over 27 terabases of RNA-sequencing data on <em>Arabidopsis thaliana</em> from over 300 peer-reviewed studies and 200 treatment conditions to investigate this hypothesis. Consistent with relaxed selection, genes with more treatment-specific expression have higher levels of nucleotide diversity and divergence at nonsynonymous sites but lack stronger signals of positive selection. This result persisted even after controlling for expression level, gene length, GC content, the tissue specificity of expression, and technical variation between studies. Overall, our investigation supports the existence of a hypothesized trade-off between the environment specificity of a gene's expression and the strength of selection on said gene in <em>A. thaliana</em>. Future studies should leverage multiple genome-scale datasets to tease apart the contributions of many variables in limiting plasticity evolution.</p>
A Database Survey of Comparison The Risk of Haemorrhage Between Vortioxetine Tablet Treatment and Selective Serotonin Reuptake Inhibitor (SSRI) Treatment in Participants With Depression
ClinicalTrials.gov study NCT05932407. IPD Sharing: YES. Countries: 1. Publications: 1.
Data for: Weaker selection on genes with treatment-specific expression consistent with a limit on plasticity evolution in Arabidopsis thaliana
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Performance of virtual screening against GPCR homology models: Impact of template selection and treatment of binding site plasticity
<p>Rational drug design for G protein-coupled receptors (GPCRs) is limited by the small number of available atomic resolution structures. We assessed the use of homology modeling to predict the structures of two therapeutically relevant GPCRs and strategies to improve the performance of virtual screening against modeled binding sites. Homology models of the D<sub>2</sub> dopamine (D<sub>2</sub>R) and serotonin 5-HT<sub>2A</sub> receptors (5-HT<sub>2A</sub>R) were generated based on crystal structures of 16 different GPCRs. Comparison of the homology models to D<sub>2</sub>R and 5-HT<sub>2A</sub>R crystal structures showed that accurate predictions could be obtained, but not necessarily using the most closely related template. Assessment of virtual screening performance was based on molecular docking of ligands and decoys. The results demonstrated that several templates and multiple models based on each of these must be evaluated to identify the optimal binding site structure. Models based on aminergic GPCRs displayed ligand enrichment and there was a trend toward improved virtual screening performance with increasing binding site accuracy. The best models even displayed ligand enrichment better than that of the D<sub>2</sub>R and 5-HT<sub>2A</sub>R crystal structures. Methods to consider binding site plasticity were explored to further improve predictions. Molecular docking to ensembles of structures did not outperform the best individual binding site models, but could increase the diversity of hits from virtual screens and be advantageous for GPCR targets with few known ligands. Molecular dynamics refinement resulted in moderate improvements of structural accuracy and the virtual screening performance of snapshots was either comparable to or worse than that of the raw homology models. These results provide guidelines for successful application of structure-based ligand discovery using GPCR homology models.</p>
Selectivity improvement of polysulfone-zeolite templated carbon membrane by annealing and coating treatment for CO2/CH4 and H2/CH4 separation
<p>Natural gas, which majorly consists of methane (CH4), is a renewable energy source widely used as fuel, as well as hydrogen (H2). However, in its production process of each gas containing other impurity gasses. Therefore, membrane technology is needed to separate the gasses from the impurities. Mixed Matrix Membrane (MMM) is a more promising membrane compared to the others. Zeolite Templated Carbon-based MMM offers a good separation performance because of ZTC's large surface area and well-defined pore structure. However, the interfacial void in MMM is challenging to be prevented, which contributes to the reduced separation performance. This study aims to enhance separation performance by modifying membrane surfaces using various methods. MMM PSF/ZTC modified by annealing at 120, 150, and 190 °C; coating using 0.01, 0.03, and 0.05 mol tetramethylorthosilicate (TMOS); and both combinations annealing at 190 °C and coating using 0.03 mol TMOS. MMM PSF/ZTC was successfully significantly improved CO2/CH4 selectivity by both combinations of annealed at 190 °C and coated 0.03 mol TMOS from 1.37 to 5.90 (331%) and H2/CH4 selectivity by coating with 0.03 mol TMOS from 4.58 to 65.76 (1378%). The enhancement of selectivity was due to structural changes of the membrane that was denser and smoother, which SEM and AFM observed. In this study, annealing and coating treatment are the methods that can use for improving the polymer matrix and filler particle adhesion.</p>
Treatment of Uterine Fibroids With the Selective Progesterone Receptor Modulator CDB-2914
ClinicalTrials.gov study NCT00290251. IPD Sharing: Not stated. Countries: 1. Publications: 9.
Selective Neoadjuvant Treatment According to Immunohistochemical Subtype for HER2 Negative Breast Cancer Patients
ClinicalTrials.gov study NCT00432172. IPD Sharing: Not stated. Countries: 1. Publications: 8.
Optimizing the Effectiveness of Selective Serotonin Reuptake Inhibitors (SSRIs) in Treatment-Resistant Depression
ClinicalTrials.gov study NCT00093847. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Randomized Clinical Trial: Expectant Management vs Laser Treatment of Monochorionic Twins With Severe Selective Intrauterine Growth Retardation and Absent or Reverse Diastolic Flow in the Umbilical Ar
ClinicalTrials.gov study NCT01177553. IPD Sharing: Not stated. Countries: 1. Publications: 32.
Pilot Study Using Molecular Profiling to Find Potential Targets & Select Treatments for Pts With Met br ca
ClinicalTrials.gov study NCT01074814. IPD Sharing: NO. Countries: 1. Publications: 1.
Selecting Effective Combinations of Treatment for Low Back Pain
ClinicalTrials.gov study NCT03520387. IPD Sharing: YES. Countries: 1. Publications: 1.
Treatment of Social Anxiety Disorder and Selective Mutism
ClinicalTrials.gov study NCT02554929. IPD Sharing: Not stated. Countries: 1. Publications: 2.
MRI Based Active Selection for Treatment Trial
ClinicalTrials.gov study NCT02242773. IPD Sharing: NO. Countries: 1. Publications: 1.
Micropulse Laser Trabeculoplasty (MLT) Versus Selective Laser Trabeculoplasty (SLT) for Treatment of Open Angle Glaucoma
ClinicalTrials.gov study NCT01956942. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Haploidentical CD34+ Selected Cells Combined With Single Unit Umbilical Cord Blood Transplant for Treatment of High-risk Hematologic Disorders
ClinicalTrials.gov study NCT03093844. IPD Sharing: NO. Countries: 1. Publications: 4.
SELECT2: A Randomized Controlled Trial to Optimize Patient's Selection for Endovascular Treatment in Acute Ischemic Stroke
ClinicalTrials.gov study NCT03876457. IPD Sharing: NO. Countries: 6. Publications: 11.
Pharmacogenomically Selected Treatment for Gastric and Gastroesophageal Junction (GEJ) Tumors
ClinicalTrials.gov study NCT00515216. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Study of Flexible or Fixed Dose LY2216684 as Adjunctive Treatment for Participants With Major Depressive Disorder Who Have Had a Partial Response to Selective Serotonin Reuptake Inhibitor (SSRI) Tre
ClinicalTrials.gov study NCT01187407. IPD Sharing: Not stated. Countries: 7. Publications: 2.
Data from: Impact of treatment and re-treatment with Artemether-Lumefantrine and Artesunate-Amodiaquine on selection of Plasmodium falciparum Multidrug Resistance Gene-1 polymorphisms in the Democratic Republic of Congo and Uganda
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Allen Brain Atlas
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Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.