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ShareScore release 0.9.0
Dataset results
17 results for “tumor-derived exosomes”
Data for: Sensitive and specific detection of tumor-derived exosomes using nanopore-crystal microchips
<p>Tumor-derived exosomes (tExos) have emerged as promising circulating biomarkers for early cancer diagnosis. However, the sensitivity and specificity of existing assays often limit the clinical translation of tExos. In this study, we present a highly versatile microfluidic platform, termed the nanopore-crystal microchip (NC-Chip), for specific isolation and ultrasensitive detection of tExos in as little as 0.5 μL of plasma samples from pancreatic cancer (PC) patients. The NC-Chip incorporates a herringbone-patterned hierarchical porous hydrogel scaffold, enabling fluid manipulation, size exclusion, immunoaffinity capture, and signal amplification. These integrated features significantly enhance the sensitivity and specificity of tExos assays in complex clinical scenarios. Utilizing an eight-protein signature, the NC-Chip can distinguish patients with pancreatitis and non-metastatic PC with 100% accuracy in the training cohort and 94.9% accuracy in the validation cohort. This platform is sensitive, specific, inexpensive, and only needs small-volume samples, offering a powerful exosome-based liquid biopsy tool for early PC diagnosis.</p>
Data for: Simultaneous subset tracing and miRNA profiling of tumor-derived exosomes via dual-surface-protein orthogonal barcoding
<p><span>The clinical potential of miRNA-based liquid biopsy has been largely limited by the heterogeneous sources in plasma and tedious assay processes. </span><span>Here we develop a precise and robust one-pot assay called dual-surface-protein</span><span>-guided</span><span> orthogonal recognition of tumor-derived exosomes and in-situ profiling of microRNAs (SORTER) to detect tumor-derived exosomal miRNAs and enhance the diagnostic accuracy of prostate cancer (PCa). The SORTER utilizes two allosteric aptamers against exosomal marker CD63 and tumor marker EpCAM to create an orthogonal labeling barcode and achieve selective sorting of tumor-specific exosome subtypes. Furthermore, the labeled barcode on tumor-derived exosomes initiated targeted membrane fusion with liposome probes to import miRNA detection reagents, enabling in-situ sensitive profiling of tumor-derived exosomal miRNAs. With a signature of six miRNAs, SORTER differentiated PCa and benign prostatic hyperplasia with an accuracy of 100%. Notably, the diagnostic accuracy reached 90.6% in the classification of metastatic and non-metastatic PCa. We envision that the SORTER will promote the clinical adaptability of miRNA-based liquid biopsy.</span></p>
Data for: Simultaneous subset tracing and miRNA profiling of tumor-derived exosomes via dual-surface-protein orthogonal barcoding
Open the record for dataset details and reuse information.
Data for: Sensitive and specific detection of tumor-derived exosomes using nanopore-crystal microchips
Open the record for dataset details and reuse information.
Tumor-derived exosomes modulate PD-L1 expression in monocytes
GEO Series GSE83539. Homo sapiens. 8 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Tumor-derived exosomal miR-181a-5p activates hepatic stellate cells to promote liver metastasis of colorectal cancer
GEO Series GSE141997. Homo sapiens. 12 samples. Type: Non-coding RNA profiling by array.
PD-L2 of tumor-derived exosomes mediates the immune escape of cancer cells via the impaired T cell function
GEO Series GSE242798. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
lncRNA and mRNA profiles of plasma and tumor-derived exosomes of cardiac myxoma-related ischemic stroke
GEO Series GSE272078. Homo sapiens. 20 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Amiloride ameliorates muscle wasting in cancer cachexia through inhibiting tumor-derived exosome release
GEO Series GSE173250. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
Tumor-derived exosomal lncRNA SNHG4 promotes triple-negative breast cancer progression by targeting XPO5
GEO Series GSE300559. Homo sapiens. 6 samples. Type: Expression profiling by array; Non-coding RNA profiling by array.
Gene expression signatures for primary tumor and tumor-derived exosomes
GEO Series GSE80678. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
miRNA profiles of plasma and tumor-derived exosomes of cardiac myxoma-related ischemic stroke
GEO Series GSE272079. Homo sapiens. 20 samples. Type: Non-coding RNA profiling by high throughput sequencing.
A Pilot Study of Tumor-Derived Exosomes as Diagnostic and Prognostic Markers in Breast Cancer Patients Receiving Neoadjuvant Chemotherapy
ClinicalTrials.gov study NCT01344109. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Tumor-Derived Exosomal CCT6A Serves as a Matchmaker Introducing Chemokines to Tumor-Associated Macrophages in Pancreatic Ductal Adenocarcinoma [human RNA-seq]
GEO Series GSE278909. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Tumor-derived exosomal miR-204 enhances white adipose tissue browning to promote cancer associated cachexia
GEO Series GSE222380. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Tumor-Derived Exosomal CCT6A Serves as a Matchmaker Introducing Chemokines to Tumor-Associated Macrophages in Pancreatic Ductal Adenocarcinoma [mouse RNA-seq]
GEO Series GSE278339. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
Tumor-derived exosomal lnc-Sox2ot promotes EMT and stemness by acting as a ceRNA in pancreatic carcinoma
GEO Series GSE98591. Homo sapiens. 2 samples. Type: Non-coding RNA profiling by array.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.