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75 results for “ultrafiltration”
Dataset related to article "Role of ultrastructural determinants of glomerular permeability in ultrafiltration function loss".
<p><em>The files contain the raw data related to the manuscript: "Role of ultrastructural determinants of glomerular permeability in ultrafiltration function loss" available at <a href="https://insight.jci.org/articles/view/137249">https://insight.jci.org/articles/view/13724</a>9.</em></p> <p><strong>Datasets:</strong></p> <p><strong>Scripts for CFD simulation of water passage through the glomerular filtration barrier (GFB) of Wistar, MWF and MWF-treated rats:</strong></p> <p><strong>STL_models</strong> - contains STL models of the unit cell of GFB reconstructed for the three groups of rats (i.e., WIST, MWF and MWFL). The dimensions assumed are presented in tables 2 and 4 in the main text and well explained in the Supplemental Material.</p> <p><strong>CFD_cases</strong> – contains cases in .rar archives for each group of rats; each case includes scripts which needed to run a CFD simulation of steady for incompressible, turbulent flow with porosity treatment, using the <strong><em>porousSimpleFoam</em></strong> solver in OpenFOAM. OpenFOAM version 6 (openfoam.org) was used for generating all data presented in this paper, but scripts should run well with updated versions.</p> <p><strong>Figure 1_Pores morphometrical analysis.xlsx </strong>- dataset for the calculation of distribution of slit pore size. These data are presented in Figure 1. </p> <p><strong>Figure 2_subpodocyte space morphometry.xlsx </strong>- dataset for the quantification of subpodocyte area. These data are presented in Figure 2. </p> <p><strong>Figure 5_CD151 and a3 integrin expression.xlsx </strong>- dataset related to the quantification of CD151, a3 integrin and their colocalization. These data are presented in Figure 5. </p> <p><strong>k_SupplTable2.xlsx</strong> – dataset for the calculation and total and relative permeability of each structural layer of GFB. These data are presented in Supplemental Table 2.</p> <p><strong>Neal-model_graphs_Figure4_SupplFigure3.xlsx</strong> - dataset for the calculation and of hydraulic resistances of GFB using the models of Neal et al. (2007). These data are presented in Figure 4 and Supplemental Figure 3.</p> <p><strong>Table 1_Systemic parameters.xlsx </strong>- dataset related to the systemic parameters. These data are presented in Table 1.</p> <p><strong>Table 2_Morphometric characterization.xlsx </strong>- dataset related to the morphometric characterization of epithelial slit pores and GBM. These data are presented in Table 2. </p> <p> </p> <p><strong>Abstract of the manuscript</strong></p> <p>The epithelial filtration slit is a crucial component of the glomerular capillary membrane, which is essential for maintaining glomerular filtration function. Though chronic kidney diseases are an immense clinical problem, the mechanisms through which structural alterations reduce glomerular water filtration have not yet been understood completely. To investigate the mechanisms underlying filtration function loss, we studied rats with spontaneously occurring progressive kidney disease, either treated with angiotensin II antagonist or untreated, combining high-resolution electron microscopy of the glomerular capillary wall with theoretical water filtration modeling. Under pathological conditions, epithelial filtration pores and the extension of the subpodocyte space were larger than in normal controls. Numerical analyses indicated that these ultrastructural changes increased hydraulic resistance of the glomerular capillary wall by extending coverage of the filtration barrier by the subpodocyte space, with the changes in hydrodynamic forces acting on podocytes likely being responsible for their detachment. Angiotensin II inhibition normalized the subpodocyte space's hydraulic resistance, restored mechanical podocyte load, and preserved CD151-α3 integrin complex assembly, improving podocyte adherence and survival. Our results show that ultrastructural changes in podocytes are major determinants of the hydraulic resistance of the glomerular capillary wall and highlight the mechanism of podocyte loss in kidney disease progression, as well as the mechanisms underlying angiotensin II inhibition.</p>
Long-Term Stable Metal Organic Framework (MOF) Based Mixed Matrix Membranes for Ultrafiltration
<p><strong>Preprint available here:</strong> Al-shaeli, Muayad; Smith, Stefan J. D.; Jiang, Shanxue; Wang, Huanting; Zhang, Kaisong; Ladewig, Bradley P. (2020): Long-Term Stable Metal Organic Framework (MOF) Based Mixed Matrix Membranes for Ultrafiltration. ChemRxiv. Preprint. <a href="https://doi.org/10.26434/chemrxiv.13399367.v1">https://doi.org/10.26434/chemrxiv.13399367.v1</a></p> <p>Published manuscript: Muayad Al-Shaeli, Stefan J.D. Smith, Shanxue Jiang, Huanting Wang, Kaisong Zhang, Bradley P. Ladewig,<br> Long-term stable metal organic framework (MOF) based mixed matrix membranes for ultrafiltration,<br> Journal of Membrane Science, 2021, 119339, <a href="https://doi.org/10.1016/j.memsci.2021.119339">https://doi.org/10.1016/j.memsci.2021.119339</a></p> <p><strong>Abstract</strong></p> <p>In this study, novel mixed matrix membranes (MMMs) were synthesized by adding metal organic frameworks (MOFs) (UiO-66 and UiO-66-NH<sub>2</sub>) to pristine and sulfonated polyethersulfone (PES). The differing synthetic method resulting in MMM where additives were grafted to the matrix polymer, or formed a natural interface, allowing the impact of these MMM features to be investigated. The composite membranes were characterised by FTIR, PXRD, water contact angle, porosity, pore size, etc. Membrane performance was investigated by water permeation flux, flux recovery ratio, fouling resistance and anti-fouling performance. The stability test was also conducted for all the prepared mixed matrix membranes. A higher reduction in the water contact angle was observed after adding both MOFs to the PES and sulfonated PES membranes compared to pristine PES membranes. An enhancement in membrane performance was observed by embedding the MOFs into PES membrane matrix, with flux increased remarkably (565 LMH for PES+UiO-66-NH<sub>2</sub> at 5% loading and 487.1 LMH for SPES-UiO-66(10% binding) while the BSA rejection was still kept at a high level. By adding the MOFs into PES matrix, the flux recovery ratio was increased greatly (more than 99% for most mixed matrix membranes). The mixed matrix membranes showed higher resistance to protein adsorption compared to pristine PES membranes. After immersing the membranes in water for 3 months, 6 months and 12 months, both MOFs were stable and retained their structure. This study indicates that UiO-66 and UiO-66-NH<sub>2</sub> are great candidates for designing long-term stable mixed matrix membranes (MMMs) for applications in water and wastewater treatment.</p>
Pure Water Permeance and Zeta Potential Data of Modified Ultrafiltration Membranes
<p>The data presented here belong to the journal article: <a title="DOI URL" href="https://doi.org/10.1021/acsami.3c18805">https://doi.org/10.1021/acsami.3c18805</a> </p> <p>The datasets contain pure water permeance and zeta potential data of electron beam-modified polymer membranes. The data were used as training data for machine learning models. Additionally, measured data for result comparison are presented.</p>
Extracorporeal Ultrafiltration (UF) vs. Usual and Customary Care for Patients With Severe Heart Failure (HF)
ClinicalTrials.gov study NCT00288587. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Ultrafiltration Profiling and Outcomes Among Individuals on Maintenance Hemodialysis
ClinicalTrials.gov study NCT03301740. IPD Sharing: NO. Countries: 1. Publications: 1.
A Net Ultrafiltration Challenge to Predict Preload-dependence (UF CHALLENGE)
ClinicalTrials.gov study NCT05214729. IPD Sharing: NO. Countries: 1. Publications: 1.
PURE-HF: Peripheral Ultrafiltration for the RElief From Congestion in Heart Failure
ClinicalTrials.gov study NCT03161158. IPD Sharing: NO. Countries: 2. Publications: 1.
Comparison Study of Daily Ultrafiltration and Twice-weekly Hemodialysis
ClinicalTrials.gov study NCT00825318. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effectiveness of Ultrafiltration in Treating People With Acute Decompensated Heart Failure and Cardiorenal Syndrome (The CARRESS Study)
ClinicalTrials.gov study NCT00608491. IPD Sharing: Not stated. Countries: 2. Publications: 6.
Ultrafiltration in Pediatric Cardiac Surgery: An Observational Cohort Study
ClinicalTrials.gov study NCT05154864. IPD Sharing: NO. Countries: 1. Publications: 4.
Global rEgistry on decongestioN Therapy Using Less invasivE UltraFiltration
ClinicalTrials.gov study NCT02769351. IPD Sharing: NO. Countries: 3. Publications: 2.
Data from: Evaluation of novel large cut-off ultrafiltration membranes for adenovirus serotype 5 (Ad5) concentration.
The purification of virus particles and viral vectors for vaccine and gene therapy applications is gaining increasing importance in order to deliver a fast, efficient, and reliable production process. Ultrafiltration (UF) is a widely employed unit operation in bioprocessing and its use is present in several steps of the downstream purification train of biopharmaceuticals. However, to date few studies have thoroughly investigated the performance of several membrane materials and cut-offs for virus concentration/diafiltration. The present study aimed at developing a novel class of UF cassettes for virus concentration/diafiltration. A detailed study was conducted to evaluate the effects of (i) membrane materials, namely polyethersulfone (PES), regenerated cellulose (RC), and highly cross-linked RC (xRC), (ii) nominal cut-off, and (iii) UF device geometry at different production scales. The results indicate that the xRC cassettes with a cut-off of approximately 500 kDa are able to achieve a 10-fold concentration factor with 100% recovery of particles with a process time twice as fast as that of a commercially available hollow fiber. DNA and host cell protein clearances, as well as hydraulic permeability and fouling behavior, were also assessed.
Pre Bypass Ultrafiltration (PBUF) in Children Requiring Cardiopulmonary Bypass
ClinicalTrials.gov study NCT03576534. IPD Sharing: NO. Countries: 1. Publications: 14.
Does Modified Ultrafiltration Affect Thromboelastography Results?
ClinicalTrials.gov study NCT03214120. IPD Sharing: NO. Countries: 1. Publications: 10.
A Performance Analysis of the Peritoneal Ultrafiltration (PUF) Achieved With the Carry Life® UF
ClinicalTrials.gov study NCT03724682. IPD Sharing: NO. Countries: 1. Publications: 1.
The Effect of Dapagliflozin on Ultrafiltration Among Peritoneal Dialysis Patients
ClinicalTrials.gov study NCT04923295. IPD Sharing: YES. Countries: 1. Publications: 1.
Modified Ultrafiltration in Cardiac Surgery
ClinicalTrials.gov study NCT00998647. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Ultrafiltration Versus Intravenous (IV) Diuretics for Patients Hospitalized for Acute Decompensated Heart Failure: (UNLOAD)
ClinicalTrials.gov study NCT00124137. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Parameters of Cardiac Indices on the Ultrasonic Cardiac Output Monitor As Potential Indicators for Predicting the Achievement of Ultrafiltration Endpoint for Acute Heart Failure Treatment
ClinicalTrials.gov study NCT06533124. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Ultrafiltration Versus Medical Therapies in the Management of the Cardio Renal Syndrome
ClinicalTrials.gov study NCT02846337. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.