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120
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ShareScore release 0.9.0
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120 results for “unfolded protein response”
The c.119-123dup5bp mutation in human gamma-C-crystallin destabilizes the protein and activates the unfolded protein response to cause highly variable cataracts
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The Seven Trial: Exploiting the Unfolded Protein Response
ClinicalTrials.gov study NCT06076837. IPD Sharing: NO. Countries: 1. Publications: 2.
Data from: Uncovering a mitochondrial unfolded protein response in corals and its role in adapting to a changing world
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['Relevance of Unfolded Protein Response to Spaceflight-Induced Transcriptional Reprogramming in Arabidopsis']
['Plants are primary producers of food and oxygen on Earth and will likewise be indispensable to the establishment of large-scale sustainable ecosystems and human survival in space. To contribute to the understanding of how plants respond to spaceflight stresses, we examined the relevance of the unfolded protein response (UPR), a conserved signaling cascade that responds to a number of unfavorable environmental stresses, in the model plant species Arabidopsis thaliana. To do so, we compared the transcriptional responses of wild type and UPR-defective seedlings to spaceflight during the SpaceX-CRS12 mission to the International Space Station. We established that orbital culture substantially altered the expression of hundreds of stress related genes compared to ground control conditions. Although many of these genes were differentially regulated in the UPR mutants in the ground control conditions compared to wild type, their expression was largely equalized in all genotypes by flight. Our results have yielded new information on how plants respond to growth in orbit and support the hypothesis that spaceflight induces the activation of signaling pathways that compensate for the loss of UPR regulators in the control of downstream transcriptional regulatory networks.']
Transcriptomic analysis uncovers an unfolded protein response in ADNP syndrome
GEO Series GSE280293. Homo sapiens. 27 samples. Type: Expression profiling by high throughput sequencing.
Differential unfolded protein response regulation in KRAS silencing sensitive versus innately resistant colorectal cancer cells [LS174T]
GEO Series GSE254833. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
A dynamic unfolded protein response contributes to the control of cortical neurogenesis
GEO Series GSE74683. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing; Other.
Systems-level computational translation of mouse and human transcriptomics reveals a role for the unfolded protein response in Mycobacterium tuberculosis infection
GEO Series GSE281697. Mus musculus. 20 samples. Type: Expression profiling by high throughput sequencing.
Effects of different diets on autophagy control and unfolded protein response in the aging heart
GEO Series GSE299132. Mus musculus. 20 samples. Type: Expression profiling by high throughput sequencing.
An inter-chromosomal transcription hub activates the unfolded protein response in plasma cells
GEO Series GSE113014. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
Fatty acid binding proteins contribute to multiple myeloma cell maintenance through regulation of Myc, the unfolded protein response, and metabolism
GEO Series GSE190699. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Sequencing of Argonaute-bound miRNA/mRNA hybrids reveals regulation of the unfolded protein response by microRNA-320a
GEO Series GSE164634. Homo sapiens. 43 samples. Type: Other; Expression profiling by high throughput sequencing.
Transcription factor ATF4 directs basal and select gene expression in the unfolded protein response and cholesterol metabolism in liver
GEO Series GSE76771. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Montelukast counteracts the influenza virus-induced block in unfolded protein stress response and reduces virus multiplication
GEO Series GSE68673. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Loss of subcellular lipid transport due to ARV1 deficiency disrupts organelle homeostasis and activates the unfolded protein response
GEO Series GSE26801. Saccharomyces cerevisiae. 14 samples. Type: Expression profiling by array.
Wnt inhibitors reduce the unfolded protein response and enhance bortezomib-induced cell death in multiple myeloma
GEO Series GSE219133. Homo sapiens. 10 samples. Type: Expression profiling by high throughput sequencing.
Chondrodysplasia-inducing COL2A1 p.Gly1170Ser causes an ER storage defect without associated unfolded protein response in chondronoids
GEO Series GSE244375. Homo sapiens. 78 samples. Type: Expression profiling by high throughput sequencing.
Role of Hac1 in unfolded protein response in Candida parapsilosis
GEO Series GSE120094. Candida parapsilosis. 12 samples. Type: Expression profiling by high throughput sequencing.
Protein aggregation in plant mitochondria lacking Lon1 inhibits translation and induces unfolded protein responses
GEO Series GSE216535. Arabidopsis thaliana. 6 samples. Type: Expression profiling by high throughput sequencing.
The IRE1α-XBP1 Pathway of the Unfolded Protein Response is Required for Adipogenesis
GEO Series GSE15771. Mus musculus. 2 samples. Type: Expression profiling by array.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.