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49 results for “vaginal microbiome”
VMGC - Human Vaginal Microbiome Genome Collection
<p>The VMGC is a large-scale reference genome resource of the human vaginal microbiome, including over 33,000 genomes derived from 786 prokaryotes, 11 fungi, and 4,263 viruses associated with the human vagina. In terms of representation, the VMGC demonstrates high efficiency in capturing microbial sequences, with a median mapping rate of 91.7% across 4,472 vaginal metagenomic samples obtained from 14 countries.</p>
The canine vaginal microbiome in heat does not influence fertility in healthy breeding bitches
<p>A healthy and balanced vaginal microbiome is often thought to be an important prerequisite for successful breeding and healthy litters. Previous studies investigating the influence of canine vaginal bacteria on fertility mostly relied on aerobic culturing. In recent years, culture-independent methods, such as next-generation sequencing (NGS), have become popular. With the ability to analyze the microbiome as a whole, research in this field has made notable advances. This is the first study to correlate NGS data of the canine vaginal microbiome in heat with fertility data. Healthy breeding bitches (n=80) presented for routine pre-breeding examination were sampled during early heat and mated after ovulation. A vaginal sample was taken for NGS analysis and microbiological culture. Additionally, a blood sample was collected. Fertility data (mating, pregnancy, delivery, litter size) were assessed. NGS revealed a diverse microbiome in all the samples. Bioinformatics and statistical analysis did not provide evidence of larger differences in the microbiome of those bitches that became pregnant and those that did not. </p> <p> </p>
Data from: Vaginal host immune-microbiome interactions in a cohort of primarily African-American women who ultimately underwent spontaneous preterm birth or delivered at term
<p><strong>Background</strong>: Recent studies suggest that alterations in the vaginal microbiome allow for the assessment of the risk for spontaneous preterm birth (PTB), the leading cause of neonatal morbidity and mortality worldwide. However, the associations between the local immune response and the vaginal microbiome are still poorly understood. Herein, we characterize the vaginal host immune-microbiome interactions in women who ultimately underwent PTB and in those who delivered at term.</p> <p><strong>Methods</strong>: Vaginal fluid samples from 52 pregnant women (of whom 18 underwent PTB and 34 delivered at term) were collected from 10-32 weeks in a case-control study. Concentrations of 33 immune mediators were determined using sensitive and specific immunoassays. The previously published 16S rRNA gene sequence and bacterial phylotype data of these subjects were utilized in this study. Linear mixed effects models were utilized to test associations between vaginal immune mediator concentrations and bacterial phylotype relative abundances.</p> <p><strong>Results</strong>: 1) Specific immune mediators (β-defensins 2 and 3, IL-1β, CXCL10, CCL2, CCL3, SLPI, and VEGF) correlated with 18 different vaginal bacterial phylotypes in the overall study population; 2) vaginal concentrations of CXCL10, CCL2, CCL3, SLP1 and VEGF negatively correlated with non-Lactobacillus members of the vaginal microbiome; 3) vaginal concentrations of CXCL10 were negatively correlated with 15 bacterial phylotypes, most of which are typical members of Community State Type IV of the vaginal microbiome, such as Gardnerella vaginalis, Megasphaera sp. type 1, and Atopobium vaginae; 4) Gemella spp. were negatively correlated with vaginal concentrations of VEGF, CCL2, CCL3, SLPI, and CXCL10; 5) when comparing PTB cases to term controls, five soluble immune mediators (CCL26, CCL22 and CCL2, CXCL10 and IL-16), and especially CCL26, were negatively correlated with five typical members of Community State Type IV: Sneathia sanguinegens, Parvimonas micra, Veillonellaceae, BVAB2, and Gemella spp; and 6) Sneathia sanguinegens had stronger negative associations with all five soluble immune mediators (CCL26, CCL22 and CCL2, CXCL10 and IL-16) in PTB cases than in term controls.</p> <p><strong>Conclusions</strong>: The assessment of vaginal host immune-microbiome interactions revealed that specific soluble immune mediators, mainly CXCL10, negatively correlated with typical members of Community State Type IV of the vaginal microbiome. In addition, this assessment particularly showed that Sneathia sanguinegens had stronger negative associations with different immune mediators, including CXCL10 and CCL26, in women who ultimately had a PTB compared to those who delivered at term. These findings provide insight into the vaginal host immune-microbiome interactions in normal and complicated pregnancies.</p>
Supplemental Data for Comprehensive Microbiome Landscape (Bladder, Intestinal, Vaginal) in Bladder Cancer: A Systematic Review
<p>Supplemental Data for: "<em>Comprehensive Microbiome Landscape (Bladder, Intestinal, Vaginal) in Bladder Cancer: A Systematic Review"</em></p>
Processed data for Microdiversity of the Vaginal Microbiome is Associated with Preterm Birth.
<p>Processed data for the manuscript Microdiversity of the Vaginal Microbiome is Associated with Preterm Birth.</p>
Effect of Flourish HEC Vaginal Care System on BV Recurrence and the Vaginal Microbiome
ClinicalTrials.gov study NCT05701722. IPD Sharing: Not stated. Countries: 1. Publications: 14.
Efficacy and Safety of CO₂ Laser Therapy Combined With Collagen Cream in Managing Vulvo-Vaginal Atrophy: A Randomized, Controlled Study on Symptom Relief and Microbiome Modulation
ClinicalTrials.gov study NCT07246616. IPD Sharing: NO. Countries: 1. Publications: 1.
Vaginal Microbiome Transplantation for Recurrent Bacterial Vaginosis
ClinicalTrials.gov study NCT04517487. IPD Sharing: NO. Countries: 1. Publications: 1.
Effect of Vaginal Estrogen on Alterations in the Urine Microbiome of Menopausal Women With Overactive Bladder
ClinicalTrials.gov study NCT06780163. IPD Sharing: YES. Countries: 1. Publications: 7.
Effects of Lactobacillus Pentosus KCA1 on the Gut and Vaginal Microbiome of Women With Bacterial Vaginosis
ClinicalTrials.gov study NCT04329338. IPD Sharing: NO. Countries: 1. Publications: 1.
Pubic Hair and the Urinary and Vaginal Microbiome
ClinicalTrials.gov study NCT03272204. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Evaluation of the Relationship Between Vaginal and Lower Urinary Tract Microbiomes and Infection After Hysterectomy
ClinicalTrials.gov study NCT02751073. IPD Sharing: NO. Countries: 1. Publications: 1.
Modulating the Vaginal Microbiome After Implantation Failure
ClinicalTrials.gov study NCT03843112. IPD Sharing: NO. Countries: 1. Publications: 1.
Genital Tract Infections, the Vaginal Microbiome and Gestational Age at Birth Among Pregnant Women in South Africa
ClinicalTrials.gov study NCT06131749. IPD Sharing: NO. Countries: 1. Publications: 1.
Vaginal, Placental and Neonatal Buccal Mycobiota and Microbiome in Preterm Birth
ClinicalTrials.gov study NCT04165252. IPD Sharing: YES. Countries: 1. Publications: 10.
Vaginal Microbiome Seeding and Health Outcomes in Cesarean-delivered Neonates.
ClinicalTrials.gov study NCT03298334. IPD Sharing: YES. Countries: 1. Publications: 4.
Vaginal and Urinary Microbiome Trial
ClinicalTrials.gov study NCT02869165. IPD Sharing: NO. Countries: 1. Publications: 21.
Data from: Vaginal host immune-microbiome interactions in a cohort of primarily African-American women who ultimately underwent spontaneous preterm birth or delivered at term
Open the record for dataset details and reuse information.
Exploring the Effects of an Intravaginal Lactic Acid Gel on the Vaginal Microbiome
ClinicalTrials.gov study NCT05753813. IPD Sharing: NO. Countries: 1. Publications: 0.
Menopausal Vaginal Microbiome
ClinicalTrials.gov study NCT05122065. IPD Sharing: NO. Countries: 0. Publications: 54.
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International Brain Laboratory public data
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OpenNeuro
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