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149 results for “vascular growth”
Vascular Endothelial Growth Factor-B (VEGF-B) Blockade With the Monoclonal Antibody CSL346 in Subjects With Diabetic Kidney Disease
ClinicalTrials.gov study NCT04419467. IPD Sharing: YES. Countries: 6. Publications: 1.
Data from: Acute cytotoxicity and increased vascular endothelial growth factor after in vitro nitrogen mustard vapor exposure
<p>RATIONALE: Nitrogen mustard (NM) is a highly toxic alkylating agent. It is classified as chemical threat due to its potential use as a warfare agent. When inhaled, mustard exposure can cause both acute and chronic lung injury. The aims of this study are to develop an in vitro culture system for modeling mustard-induced airway injury and to identify growth factors contributing to airway pathology.</p> <p><br> METHODS: Primary human bronchial epithelial cells co-cultured with primary human pulmonary endothelial cells were exposed to NM (25, 50, 100, 250 or 500 µM) or PBS (control) for 1 hour. Lactate dehydrogenase (LDH) and trans-epithelial electrical resistance (TEER) were measured prior to and 24 hours after NM exposure. Endothelial cultures were then stained for live/dead staining. Exposed airway media was also analyzed for growth factors using Luminex multiplex technology. </p> <p><br> RESULTS: A one-hour NM vapor exposure increased supernatant LDH and decreased TEER at 24 hours for all cultures exposed to NM concentrations greater than or equal to 50 µM. Evidence of endothelial cell death occurred at NM concentrations of 250 and 500 µM. Vascular endothelial growth factor (VEGF) signaling, specifically VEGF-A and placental growth factor (PlGF), increased in NM-exposed co-culture media compared to PBS controls. </p> <p><br> CONCLUSIONS: NM vapor exposure causes significant airway epithelial and endothelial injury. Increased VEGF signaling occurred in airway co-cultures exposed to higher NM concentrations with concurrent endothelial cell death. Future studies are required to validate the role of VEGF signaling in both acute and chronic mustard-induced airway pathology. </p>
Influence of polymorphisms in the vascular endothelial growth factor gene on allograft rejection after kidney transplantation: a meta-analysis
<p><span><b><i>Purpose</i></b><i> </i>Reported associations of allograft rejection in kidney transplant patients with <i>VEGF</i> single nucleotide polymorphisms (SNPs) have been inconsistent between studies, which prompted a meta-analysis to obtain more precise estimates.</span></p> <p><span><b><i>Methods</i></b><i> </i>Using the PICO elements, kidney transplant patients (P) were compared by genotype data between rejectors (I) and non-rejectors (C) in order to determine the risk of allograft rejection (O) attributed to the <i>VEGF</i> SNPs. Literature search of four databases yielded seven articles. To calculate risks for allograft rejection, four SNPs were examined. Meta-analysis treatments included outlier and subgroup analyses, the latter was based on ethnicity (Indians/Caucasians) and rejection type (acute/chronic). Multiple comparisons were corrected with the Bonferroni test. </span></p> <p><span><span><b><i>Results</i></b> Five highly significant outcomes (P<sup>a</sup> < 0.01) survived Bonferroni correction, one of which showed reduced risk for the <i>var</i> allele (OR 0.61, 95% CI 0.45-0.82). The remaining four indicated increased risk for the <i>wt</i> allele where the chronic rejection (OR 2.10, 95% CI 1.36-3.24) and Indian (OR 1.44, 95% CI 1.13-1.84) subgroups were accorded susceptibility status. </span></span></p> <p><span><b><i>Conclusions</i></b> Risk associations for renal allograft rejection were increased and reduced on account of the <i>wt</i> and <i>var</i> alleles, respectively. These findings could render the <i>VEGF</i> polymorphisms useful in the clinical genetics of kidney transplantation. </span></p>
Photoreceptor glucose metabolism determines normal retinal vascular growth
<p>The neural cells and factors determining normal vascular growth are not well defined even though vision-threatening neovessel growth, a major cause of blindness in retinopathy of prematurity (ROP) (and diabetic retinopathy), is driven by delayed normal vascular growth. We examined if hyperglycemia and low adiponectin (APN) levels delayed normal retinal vascularization, driven primarily by dysregulated photoreceptor metabolism.</p> <p>One part of the experiments was to use targeted quantitative proteomics to measure the expression of proteins with selected reaction monitoring. We measured the enzymes in glycolysis, the Krebs cycle, and several addition mitochondrial proteins.</p> <p>We found that in a neonatal mouse model of postnatal hyperglycemia modeling early ROP, hyperglycemia caused photoreceptor dysfunction and delayed neurovascular maturation associated with changes in the APN pathway; recombinant mouse APN or APN receptor agonist adipoRon treatment normalized vascular growth. APN deficiency decreased retinal mitochondrial metabolic enzyme levels particularly in photoreceptors, suppressed retinal vascular development and decreased photoreceptor platelet-derived growth factor (Pdgfb). APN pathway activation reversed these effects. Blockade of mitochondrial respiration abolished adipoRon-induced Pdgfb increase in photoreceptors. Photoreceptor-knockdown of Pdgfb delayed retinal vascular formation. Stimulation of the APN pathway might prevent hyperglycemia-associated retinal abnormalities andsuppress Phase I ROP in premature infants.</p>
Vascular Endothelial Growth Factor (VEGF) Trap-Eye: Investigation of Efficacy and Safety in Central Retinal Vein Occlusion (CRVO)
ClinicalTrials.gov study NCT01012973. IPD Sharing: Not stated. Countries: 10. Publications: 2.
Vascular Endothelial Growth Factor (VEGF) Levels in Retinal Vein Occlusion (RVO) During Anti-VEGF Treatment
ClinicalTrials.gov study NCT04707625. IPD Sharing: NO. Countries: 1. Publications: 4.
PAVES: Pegfilgrastim Anti-vascular Endothelial Growth Factor (VEGF) Evaluation Study
ClinicalTrials.gov study NCT00911170. IPD Sharing: Not stated. Countries: 17. Publications: 1.
A Retrospective Study of Anti-Vascular Endothelial Growth Factor (VEGF) Injections for Retinal Vein Occlusion or Diabetic Macular Edema
ClinicalTrials.gov study NCT01918371. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Safety and Efficacy of Repeated Intravitreal Administration of Vascular Endothelial Growth Factor (VEGF) Trap in Patients With Wet Age-Related Macular Degeneration (AMD)
ClinicalTrials.gov study NCT00320788. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Sirolimus Versus Anti-Vascular Endothelial Growth Factor (antiVEGF) for Wet AMD
ClinicalTrials.gov study NCT02357342. IPD Sharing: NO. Countries: 1. Publications: 1.
A Study of Cabozantinib Compared With Placebo in Subjects With Radioiodine-refractory Differentiated Thyroid Cancer Who Have Progressed After Prior Vascular Endothelial Growth Factor Receptor (VEGFR)
ClinicalTrials.gov study NCT03690388. IPD Sharing: NO. Countries: 25. Publications: 2.
Vascular Endothelial Growth Factor VEGF Trap-Eye:Investigation of Efficacy and Safety in Wet Age-Related Macular Degeneration(AMD)
ClinicalTrials.gov study NCT00509795. IPD Sharing: Not stated. Countries: 2. Publications: 3.
Probiotic Yogurt Supplement in Reducing Diarrhea in Patients With Metastatic Kidney Cancer Being Treated With Vascular Endothelial Growth Factor-Tyrosine Kinase Inhibitor
ClinicalTrials.gov study NCT02944617. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Safety and Efficacy of a New Treatment as Adjunctive Therapy to Anti-vascular Endothelial Growth Factor (Anti-VEGF) Treatment in Patients With Age-Related Macular Degeneration (AMD)
ClinicalTrials.gov study NCT00511706. IPD Sharing: Not stated. Countries: 9. Publications: 1.
Dorzolamide-timolol in Combination With Anti-vascular Endothelial Growth Factor Injections for Wet Age-related Macular Degeneration
ClinicalTrials.gov study NCT03034772. IPD Sharing: NO. Countries: 1. Publications: 2.
Vascular Endothelial Growth Factor (VEGF) Trap-Eye: Investigation of Efficacy and Safety in Wet Age-Related Macular Degeneration (AMD)
ClinicalTrials.gov study NCT00637377. IPD Sharing: Not stated. Countries: 26. Publications: 6.
A Study of E7080 Alone, and in Combination With Everolimus in Subjects With Unresectable Advanced or Metastatic Renal Cell Carcinoma Following One Prior Vascular Endothelial Growth Factor (VEGF)-Targe
ClinicalTrials.gov study NCT01136733. IPD Sharing: Not stated. Countries: 5. Publications: 2.
Including dynamics in the equation: Tree growth rates and host specificity of vascular epiphytes
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Data from: Acute cytotoxicity and increased vascular endothelial growth factor after in vitro nitrogen mustard vapor exposure
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Influence of polymorphisms in the vascular endothelial growth factor gene on allograft rejection after kidney transplantation: a meta-analysis
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Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.