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7 results for “whole gut transit time”
An automated sensitive approach for measuring whole gut transit time
Background <p>Commonly used methods to measure whole gut transit time in rodents have yet to combine high sensitivity, objectivity and automation. We have developed a novel method using oral gavage of non-toxic fluorescent dye particles and their detection by fluorescence imaging to enable unbiased automated detection of gut transit time simultaneously in 8 cages.</p> Methods <p>Naïve mice (n=20) were gavaged with a 4.4% suspension of fluorescent dye in CMC in 3 groups on 2 occasions. Each group was imaged in 8 cages at 5-minute intervals using blue LEDs for illumination and a Sony full-frame mirrorless camera with a green band-pass emission filter. Custom Matlab code counted the number of fluorescent boli per cage post-hoc and provided graphical and spreadsheet output. Boli counts across a wide range of parameters were compared to blind assessments by an experimenter.</p> Results <p>Fluorescent boli were detected with high sensitivity, while unstained boli were readily rejected. All cages showed no fluorescent boli for the first ~20 frames (120 minutes), after which many cages gradually show a rise to 1-6 fluorescent boli. The mean time to first fluorescent bolus in each session was 264±141 and 223±81 minutes post-gavage, with no within subject consistency. There was high correlation between automated scores and that of experimenter (r=0.95±0.02), being robust to parameter changes.</p> Conclusions & Inferences <p>This novel approach provides a reliable, automatic and low-cost method of measuring gastrointestinal transit time in mice.</p>
An automated sensitive approach for measuring whole gut transit time
Open the record for dataset details and reuse information.
Dose-Responsive Effect of Polydextrose on Whole Gut Transit Time
ClinicalTrials.gov study NCT01540669. IPD Sharing: NO. Countries: 1. Publications: 0.
Effects of Methylnaltrexone in Comparison to Naloxone on Loperamide-induced Delay of the Oro-cecal, Whole-gut and Colon Transit Time.
ClinicalTrials.gov study NCT01596764. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Effects of 500 mg Immediate Release and Extended Release Methylnaltrexone on Loperamide-induced Delay of the Oro-cecal and Whole-gut Transit Time in Healthy Subjects
ClinicalTrials.gov study NCT01596777. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Assessment of Whole Gut Transit Time Using the SmartPill Capsule
ClinicalTrials.gov study NCT00603707. IPD Sharing: Not stated. Countries: 1. Publications: 0.
The Effects of Tegaserod vs. Placebo on Whole Gut Transit Time in Patients With Chronic Constipation and Dyspepsia
ClinicalTrials.gov study NCT00277550. IPD Sharing: Not stated. Countries: 0. Publications: 0.
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