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6
datasets available to search
ShareScore release 0.9.0
Dataset results
6 results for “whole worms”
Transposase-Assisted Tagmentation: An Economical and Scalable Strategy for Single-Worm Whole-Genome Sequencing (elegans)
<p><span>AlphaMissense identifies 23 million human missense variants as likely pathogenic, but only 0.1% have been clinically classified. To experimentally validate these predictions, chemical mutagenesis presents a rapid, cost-effective method to produce billions of mutations in model organisms.</span><span> </span><span>However, the prohibitive costs and limitations in the throughput of whole-genome sequencing (WGS) technologies, crucial for variant identification, constrain its widespread application. Here, we introduce a Tn5 transposase-assisted tagmentation </span><span>technique</span><span> for conducting WGS in <em>C. elegans</em>, <em>E. coli</em>, <em>S. cervisiae</em>, and <em>C. reinhardtii</em>. This method, demands merely 2</span><span>0 minutes of hands-on time for a single worm or single-cell clones and incurs a cost below 10 US dollars. <span>It effectively pinpoints causal mutations in mutants defective in cilia or neurotransmitter secretion and in mutants synthetically sterile with a variant analogous to the oncogenic BRAF(V600E) mutation. Integrated with chemical mutagenesis, our approach can generate and identify missense variants economically and efficiently, facilitating experimental investigations of missense variants in diverse species.</span></span></p>
Transposase-Assisted Tagmentation: An Economical and Scalable Strategy for Single-Worm Whole-Genome Sequencing (other species)
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Genome-wide DNA accessibility maps and differential gene expression using ChIP-seq, ATAC-seq and RNA-seq for the human secondary fibroblast cell line hiF-T and whole worms with and without knockdown o
GEO Series GSE98758. Caenorhabditis elegans; Homo sapiens. 58 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
Whole worm transcriptomics after optogenetically induced mechanical muscle stress (OptIMMuS)
GEO Series GSE241906. Caenorhabditis elegans. 16 samples. Type: Expression profiling by high throughput sequencing.
mRNA profiling of wildtype, germline depleted, NMD mutant C. elegans whole worms and wildtype dissected gonads
GEO Series GSE64672. Caenorhabditis elegans. 5 samples. Type: Expression profiling by high throughput sequencing.
Genome-wide regulatory architecture maps using ATAC-seq, H3K4me2 ChIP-seq, and PEAT in Drosophila S2 cells and ATAC-seq in whole worms
GEO Series GSE103177. Caenorhabditis elegans; Drosophila melanogaster. 8 samples. Type: Other; Genome binding/occupancy profiling by high throughput sequencing.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.