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2,442 results for “wound”
ImageInLife20170922IP01_Sipka_Macrophage Recruitment to the Wound
<p>A tail of 3dpf transgenic zebrafish larvae (<em>tg(mpeg1:Gal4/UAS:Kaede))</em> was imaged from 1h to 6h after the tail fin amputation by ANDOR CSU-W1 confocal spinning disk on an inverted NIKON microscope (Ti Eclipse) with ANDOR Neo sCMOS camera (20x air/NA 0.75 objective, mosaic imaging 6x1 with 10% overlap between windows). Laser excitation/emission wavelength: 488/521 nm. Time step is 4min (75 repeats). Z-stack is 132μm with 4μm step (33 steps). Maximum projection is shown as well. Pixel size is 0.326μm.</p> <p>Macrophages expressing green fluorescent protein Kaede in the cytoplasm are moving toward the wound made at the tail fin.</p>
Analysis of bacteria, inflammation, and exudation in epidermal suction blister wounds reveals dynamic changes during wound healing - Dataset
<p>Dataset for "<strong>Analysis of bacteria, inflammation, and exudation in epidermal suction blister wounds reveals dynamic changes during wound healing</strong>". Data were generated from samples collected to a biobank from suction blister wounds at various timepoints during a clinical trial (<a href="https://clinicaltrials.gov/study/NCT05378997?term=NCT05378997&rank=1"><strong>NCT05378997</strong></a>). Data include concentration of bacteria in swab and dressing fluid samples, neutrophil proteins (HNE, MPO, and HBP), cytokines (IFN-gamma, interleukin IL-1beta, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12p70, IL-13, TNF-alpha) and total protein measured in dressing fluid samples, and bacterial species identified by MALDI-TOF in swab and dressing fluid samples.</p>
Dataset for "Quantification of Muscle Fiber Malformations Using Edge Detection to Investigate Chronic Wound Healing"
<p>Primary images, spreadsheets and files for "Quantification of Muscle Fiber Malformations Using Edge Detection to Investigate Chronic Wound Healing"</p>
Data and code for: a behavioural and microbiological study of wound care in Camponotus floridanus
<p><span>Open wounds pose a major infection and mortality risk in animals. To reduce these risks, many animal species apply antimicrobial compounds on their wounds.<sup> </sup>Ant societies use antimicrobial secretions from the metapleural gland to combat pathogens<sup> </sup>but this gland has been lost over evolutionary time in several genera including <em>Camponotus</em>. Using behavioral and microbiological experiments, we studied how <em>Camponotus floridanus</em> handles infected wounds without the use of antimicrobial secretions. When we experimentally injured a worker's leg at the femur, nestmates amputated the injured limb by biting the base (trochanter) of the leg until it was severed, thereby significantly increasing survival compared to ants that did not receive amputations. However, when the experimental injury was more distal (at the tibia), nestmates did not amputate the leg and instead directed more wound care to the injury site. Experimental amputations also failed to improve survival in ants with infected tibia injuries unless the leg was amputated immediately after pathogen exposure. Micro CT-scans revealed that the muscles likely responsible for leg hemolymph circulation are predominantly in the femur. Thus, it is likely that femur injuries, by attenuating hemolymph flow, provide sufficient time for workers to perform amputations before pathogen spread. Overall, this study provides the first example of the use of amputations to treat infected individuals in a non-human animal and demonstrates that ants can adapt their type of treatment depending on the location of wounds.</span></p>
Figure 6. Caspase 3 in Physical characterization and wound healing properties of Zamzam water
Figure 6. Caspase 3 levels of treatment groups. ***Extremely high significant at p <0.001 when compared to Group 1; **Highly significant lesser at p <0.01 on comparing with Group 2; ns: nonsignificant when compared to group 3 at p <0.05. Group 1: Normal control; Group 2: Disease control (wound without treatment); Group 3: Standard control (treatment with povidoneiodine cream); Group 4: Zamzam water treatment group.
Figure 7. A comparative wound healing study. A1 in Physical characterization and wound healing properties of Zamzam water
Figure 7. A comparative wound healing study. A1: Control animals, dorsal view of wound soon after creating on the 1st day; B1: Dorsal view of the wound after treating with povidone-iodine cream on 3rd day; C1: Dorsal view of the wound after treating with Zamzam water on 3rd day; A2: Control animals, dorsal view of the wound on 6th day; B2: Dorsal view of the wound after treating with povidoneiodine cream on 6th day; C2: Dorsal view of the wound after treating with Zamzam water on 6th day; A3: Control animals, dorsal view of the wound on 12th day; B3: Dorsal view of the wound after treating with povidone-iodine cream on 12th day; C3: dorsal view of the wound after treating with Zamzam water on 12th day.
Figure 2. Serum IL-1 in Physical characterization and wound healing properties of Zamzam water
Figure 2. Serum IL-1β level of treatment groups. *Significantly lesser at p <0.05 on comparing with Group 2; **Highly significant lesser at p <0.01 on comparing with group 2; ns: nonsignificant when compared to Group 3. Group 1: Normal control; Group 2: Disease control (wound without treatment); Group 3: Standard control (treatment with povidone-iodine cream); Group 4: Zamzam water treatment group.
Figure 1 in Physical characterization and wound healing properties of Zamzam water
Figure 1. Zeta potential analysis of Zamzam water. (A) Before exposure to open-air; (B) After exposure to open-air.
Figure 3. Serum IL-6 in Physical characterization and wound healing properties of Zamzam water
Figure 3. Serum IL-6 level of treatment groups. ***Extremely high significant at p <0.001; **Extremely significant at p <0.01 on comparing with Group 2; ns: nonsignificant when compared to Group 3. Group 1: Normal control; Group 2: Disease control (wound without treatment); Group 3: Standard control (treatment with povidone iodine cream); Group 4: Zamzam water treatment group.
Figure 5. Caspase 9 in Physical characterization and wound healing properties of Zamzam water
Figure 5. Caspase 9 levels of treatment groups. ***Extremely high significant at p <0.001 when compared to Group 1; **Significantly lesser at p <0.01 on comparing with Group 2; ns: nonsignificant on comparing with group 3 at p <0.05. Group 1: Normal control; Group 2: Disease control (wound without treatment); Group 3: Standard control (treatment with povidone-iodine cream); Group 4: Zamzam water treatment group.
Figure 2. Serum IL-6 in Wound-healing and cytokine-modulating potential of medicinal oil formulation comprising leaf extract of Murraya koenigii and olive oil
Figure 2. Serum IL-6 level of treatment groups. *The level of IL-6 enhanced 154% when compared to Group 1; #The level of IL-6 declined 38.86% when compared to Group 2; $The level of IL-1β declined 48.3% when compared to Group 2.
Figure 4. A in Wound-healing and cytokine-modulating potential of medicinal oil formulation comprising leaf extract of Murraya koenigii and olive oil
Figure 4. A comparative wound healing study. (A1) Control animals, Dorsal view of wound on the 3rd day after creating wound; (A2) Dorsal view of the wound after treating with povidone-iodine solution (PIS) on 3rd day; (A3) Dorsal view of the wound after treating with medicinal oil (MO) on 3rd day; (B1) Control animals, Dorsal view of wound on the 6th day after creating wound; (B2) Dorsal view of the wound after treating with povidone-iodine solution (PIS) on 6th day; (B3) Dorsal view of the wound after treating with medicinal oil (MO) on 6th day; (C1) Control animals, Dorsal view of wound on the 9th day after creating wound; (C2) Dorsal view of the wound after treating with povidone-iodine solution (PIS) on 9th day; (C3) Dorsal view of the wound after treating with medicinal oil (MO)on 9th day.
Figure 3 in Wound-healing and cytokine-modulating potential of medicinal oil formulation comprising leaf extract of Murraya koenigii and olive oil
Figure 3. Serum TNF- α level of treatment groups. *The level of TNF- α enhanced 215% when compared to Group 1; #The level of TNF- α declined 39.25% when compared to Group 2; $The level of IL-1β declined 50% when compared to Group 2.
Figure 8 in Pouteria ramiflora leaf extract on emulgel in wound healing activity in diabetic rats
Figure 8. Photomicrograph of histological sections of rats' skin wounds of Control group (Carbopol) (A, B, and C), Ethanolic extract (Ext) (D, E, F) and Gel + Ethanolic extract 2% (Ext+gel) (G, H, I) at 30 days after the skin wound injury (D, E, F). epidermis (ep); granular layer (green arrow); fibroblasts (black arrow). HE.
Figure 5 in Pouteria ramiflora leaf extract on emulgel in wound healing activity in diabetic rats
Figure 5. Quantification of inflammatory cells, fibroblasts, and angiogenesis (blood vessels) in diabetic animals' skin on groups: Control, Ext and Ext+gel, 14 days. ns (statistically not significant). DUNN's test (P=0.05).
Figure 4 in Pouteria ramiflora leaf extract on emulgel in wound healing activity in diabetic rats
Figure 4. Photomicrograph of histological sections of diabetic rats' skin wounds. (A, A1), Control, Ext (B, B1) and Ext+gel (C, C1) to 14 days after injury of the skin wound. Epidermis (ep); keratin (k); fibroblast (f); collagen fibers (c); HE. Quantification of inflammatory cells, fibroblasts, and angiogenesis in diabetic animals' skin on groups: Control, Ext and Ext+gel, DUNN's test (P=0.05).
Figure 3 in Pouteria ramiflora leaf extract on emulgel in wound healing activity in diabetic rats
Figure 3. Quantification of inflammatory cells, fibroblasts, and angiogenesis (blood vessels) in diabetic animals' skin on groups: Control; Ext and Ext+gel, 7 days. ns (statistically not significant). DUNN's test (P=0.05).
Figure 2 in Pouteria ramiflora leaf extract on emulgel in wound healing activity in diabetic rats
Figure 2. Photomicrograph of histological sections of diabetic rats' skin wounds of groups: Control, Ext and Ext+gel (A, B, C) at 7 days after injury of the skin wound (A1, B1, C1), crust, epidermis (ep); dermis (d) deep dermis with tissue granulation, fibroblasts (f); blood vessels (angiogenesis) (bv); (HE, 10 and 40x).
Figure 1 in Pouteria ramiflora leaf extract on emulgel in wound healing activity in diabetic rats
Figure 1. Chart of analysis phytochemical of Ethanolic extract of Pouteria ramiflora leaves, Campo Grande, 2016. Frequency = low (+ = 25%), moderately moderate (++ = 50%) and high intensity (+++ = 100%), besides negative (- = 0%).
Leaf wound induced ultraweak photon emission is suppressed under anoxic stress: observations of Spathiphyllum under aerobic and anaerobic conditions using novel in vivo methodology
<p>Dataset for paper: ABSTRACT: </p> <p>Plants have evolved a variety of means to energetically sense and respond to abiotic and biotic environmental stress. Two typical photochemical signaling responses involve the emission of volatile organic compounds and light. The emission of certain leaf wound volatiles and light are mutually dependent upon oxygen which is subsequently required for the wound-induced lipoxygenase reactions that trigger the formation of fatty acids and hydroperoxides; ultimately leading to photon emission by chlorophyll molecules. A low noise photomultiplier with sensitivity in the visible spectrum (300 – 720 nm) is used to continuously measure long duration ultraweak photon emission of dark-adapting whole <em>Spathiphyllum</em>leaves (<em>in vivo</em>). Leaves were mechanically wounded after two hours of dark adaptation in aerobic and anaerobic conditions. It was found that (1) nitrogen incubation did not affect the pre-wound basal photocounts; (2) wound induced leaf biophoton emission was significantly suppressed when under anoxic stress; and (3) the aerobic wound induced emission spectra observed was > 650 nm, implicating chlorophyll as the likely emitter. Limitations of the PMT photocathode’s radiant sensitivity, however, prevented accurate analysis from 700 – 720 nm. Further examination of leaf wounding profile photon counts revealed that the pre-wounding basal state (aerobic and anoxic), the anoxic wounding state, and the post-wounding aerobic state statistics all approximate a Poisson distribution. It is additionally observed that aerobic wounding induces two distinct exponential decay events. These observations contribute to the body of plant wound-induced luminescence research and provide a novel methodology to measure this phenomenon <em>in vivo</em>.</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.