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804 results for “wound healing”
Analysis of bacteria, inflammation, and exudation in epidermal suction blister wounds reveals dynamic changes during wound healing - Dataset
<p>Dataset for "<strong>Analysis of bacteria, inflammation, and exudation in epidermal suction blister wounds reveals dynamic changes during wound healing</strong>". Data were generated from samples collected to a biobank from suction blister wounds at various timepoints during a clinical trial (<a href="https://clinicaltrials.gov/study/NCT05378997?term=NCT05378997&rank=1"><strong>NCT05378997</strong></a>). Data include concentration of bacteria in swab and dressing fluid samples, neutrophil proteins (HNE, MPO, and HBP), cytokines (IFN-gamma, interleukin IL-1beta, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12p70, IL-13, TNF-alpha) and total protein measured in dressing fluid samples, and bacterial species identified by MALDI-TOF in swab and dressing fluid samples.</p>
Dataset for "Quantification of Muscle Fiber Malformations Using Edge Detection to Investigate Chronic Wound Healing"
<p>Primary images, spreadsheets and files for "Quantification of Muscle Fiber Malformations Using Edge Detection to Investigate Chronic Wound Healing"</p>
Figure 6. Caspase 3 in Physical characterization and wound healing properties of Zamzam water
Figure 6. Caspase 3 levels of treatment groups. ***Extremely high significant at p <0.001 when compared to Group 1; **Highly significant lesser at p <0.01 on comparing with Group 2; ns: nonsignificant when compared to group 3 at p <0.05. Group 1: Normal control; Group 2: Disease control (wound without treatment); Group 3: Standard control (treatment with povidoneiodine cream); Group 4: Zamzam water treatment group.
Figure 7. A comparative wound healing study. A1 in Physical characterization and wound healing properties of Zamzam water
Figure 7. A comparative wound healing study. A1: Control animals, dorsal view of wound soon after creating on the 1st day; B1: Dorsal view of the wound after treating with povidone-iodine cream on 3rd day; C1: Dorsal view of the wound after treating with Zamzam water on 3rd day; A2: Control animals, dorsal view of the wound on 6th day; B2: Dorsal view of the wound after treating with povidoneiodine cream on 6th day; C2: Dorsal view of the wound after treating with Zamzam water on 6th day; A3: Control animals, dorsal view of the wound on 12th day; B3: Dorsal view of the wound after treating with povidone-iodine cream on 12th day; C3: dorsal view of the wound after treating with Zamzam water on 12th day.
Figure 2. Serum IL-1 in Physical characterization and wound healing properties of Zamzam water
Figure 2. Serum IL-1β level of treatment groups. *Significantly lesser at p <0.05 on comparing with Group 2; **Highly significant lesser at p <0.01 on comparing with group 2; ns: nonsignificant when compared to Group 3. Group 1: Normal control; Group 2: Disease control (wound without treatment); Group 3: Standard control (treatment with povidone-iodine cream); Group 4: Zamzam water treatment group.
Figure 1 in Physical characterization and wound healing properties of Zamzam water
Figure 1. Zeta potential analysis of Zamzam water. (A) Before exposure to open-air; (B) After exposure to open-air.
Figure 3. Serum IL-6 in Physical characterization and wound healing properties of Zamzam water
Figure 3. Serum IL-6 level of treatment groups. ***Extremely high significant at p <0.001; **Extremely significant at p <0.01 on comparing with Group 2; ns: nonsignificant when compared to Group 3. Group 1: Normal control; Group 2: Disease control (wound without treatment); Group 3: Standard control (treatment with povidone iodine cream); Group 4: Zamzam water treatment group.
Figure 5. Caspase 9 in Physical characterization and wound healing properties of Zamzam water
Figure 5. Caspase 9 levels of treatment groups. ***Extremely high significant at p <0.001 when compared to Group 1; **Significantly lesser at p <0.01 on comparing with Group 2; ns: nonsignificant on comparing with group 3 at p <0.05. Group 1: Normal control; Group 2: Disease control (wound without treatment); Group 3: Standard control (treatment with povidone-iodine cream); Group 4: Zamzam water treatment group.
Figure 2. Serum IL-6 in Wound-healing and cytokine-modulating potential of medicinal oil formulation comprising leaf extract of Murraya koenigii and olive oil
Figure 2. Serum IL-6 level of treatment groups. *The level of IL-6 enhanced 154% when compared to Group 1; #The level of IL-6 declined 38.86% when compared to Group 2; $The level of IL-1β declined 48.3% when compared to Group 2.
Figure 4. A in Wound-healing and cytokine-modulating potential of medicinal oil formulation comprising leaf extract of Murraya koenigii and olive oil
Figure 4. A comparative wound healing study. (A1) Control animals, Dorsal view of wound on the 3rd day after creating wound; (A2) Dorsal view of the wound after treating with povidone-iodine solution (PIS) on 3rd day; (A3) Dorsal view of the wound after treating with medicinal oil (MO) on 3rd day; (B1) Control animals, Dorsal view of wound on the 6th day after creating wound; (B2) Dorsal view of the wound after treating with povidone-iodine solution (PIS) on 6th day; (B3) Dorsal view of the wound after treating with medicinal oil (MO) on 6th day; (C1) Control animals, Dorsal view of wound on the 9th day after creating wound; (C2) Dorsal view of the wound after treating with povidone-iodine solution (PIS) on 9th day; (C3) Dorsal view of the wound after treating with medicinal oil (MO)on 9th day.
Figure 3 in Wound-healing and cytokine-modulating potential of medicinal oil formulation comprising leaf extract of Murraya koenigii and olive oil
Figure 3. Serum TNF- α level of treatment groups. *The level of TNF- α enhanced 215% when compared to Group 1; #The level of TNF- α declined 39.25% when compared to Group 2; $The level of IL-1β declined 50% when compared to Group 2.
Figure 8 in Pouteria ramiflora leaf extract on emulgel in wound healing activity in diabetic rats
Figure 8. Photomicrograph of histological sections of rats' skin wounds of Control group (Carbopol) (A, B, and C), Ethanolic extract (Ext) (D, E, F) and Gel + Ethanolic extract 2% (Ext+gel) (G, H, I) at 30 days after the skin wound injury (D, E, F). epidermis (ep); granular layer (green arrow); fibroblasts (black arrow). HE.
Figure 5 in Pouteria ramiflora leaf extract on emulgel in wound healing activity in diabetic rats
Figure 5. Quantification of inflammatory cells, fibroblasts, and angiogenesis (blood vessels) in diabetic animals' skin on groups: Control, Ext and Ext+gel, 14 days. ns (statistically not significant). DUNN's test (P=0.05).
Figure 4 in Pouteria ramiflora leaf extract on emulgel in wound healing activity in diabetic rats
Figure 4. Photomicrograph of histological sections of diabetic rats' skin wounds. (A, A1), Control, Ext (B, B1) and Ext+gel (C, C1) to 14 days after injury of the skin wound. Epidermis (ep); keratin (k); fibroblast (f); collagen fibers (c); HE. Quantification of inflammatory cells, fibroblasts, and angiogenesis in diabetic animals' skin on groups: Control, Ext and Ext+gel, DUNN's test (P=0.05).
Figure 3 in Pouteria ramiflora leaf extract on emulgel in wound healing activity in diabetic rats
Figure 3. Quantification of inflammatory cells, fibroblasts, and angiogenesis (blood vessels) in diabetic animals' skin on groups: Control; Ext and Ext+gel, 7 days. ns (statistically not significant). DUNN's test (P=0.05).
Figure 2 in Pouteria ramiflora leaf extract on emulgel in wound healing activity in diabetic rats
Figure 2. Photomicrograph of histological sections of diabetic rats' skin wounds of groups: Control, Ext and Ext+gel (A, B, C) at 7 days after injury of the skin wound (A1, B1, C1), crust, epidermis (ep); dermis (d) deep dermis with tissue granulation, fibroblasts (f); blood vessels (angiogenesis) (bv); (HE, 10 and 40x).
Figure 1 in Pouteria ramiflora leaf extract on emulgel in wound healing activity in diabetic rats
Figure 1. Chart of analysis phytochemical of Ethanolic extract of Pouteria ramiflora leaves, Campo Grande, 2016. Frequency = low (+ = 25%), moderately moderate (++ = 50%) and high intensity (+++ = 100%), besides negative (- = 0%).
Figs 1–7 in Exocytosis of fibrous material from plasmatocytes in Scutigera coleoptrata (Chilopoda, Notostigmophora) in relation to wound healing
Figs 1–7. Plasmatocytes of Scutigera coleoptrata.1. Plasmatocyte (pl) with several grana (g) containing fibrous material. The hemocyte is attached to an axon (a). 2. Numerous grana, containing tubular fibrous substances and electron dense areas (ea). 3. Details of a granulum with an electron dense area. The arrows show a marginal detachment of tubuli from that centre; grana membrane (m). 4. Grana and areas where grana membranes (m) are dissolved; note that the fibrous tubuli remain ordered. 5. Cross sectioned fibrous tubuli (asterisk), (m) membrane. 6. Plasmatocyte, releasing tubuli in clusters (tc) into the hemolymph (h), nucleus (n). 7. Plasmatocyte, releasing tubuli singly into hemolymph. Tubuli in longitudinal section (long arrow), tubuli in cross section (short arrow). Asterisk indicates cross-sectioned tubuli.
The Effect of 10% ointment concentration of ethyl acetate subfraction of Meniran (Phyllanthus niruri L.) leaves on excision wound healing in white male rats
<p><strong>Abstract</strong></p> <p><strong>Background: </strong>Wounds are skin problems that are often experienced by humans. Effective wound healing requires a complex arrangement of various healing processes that occur continuously. The plant that has been studied to have a role in the wound healing process is the herbal extract of meniran (<em>Phyllanthus niruri</em> L). This plant can be found in almost all parts of Indonesia. However, biomedical evidence related to the effect of giving meniran (<em>Phyllanthus niruri</em> L) leaves ethyl acetate subfraction ointment preparations is still not revealed yet.</p> <p><strong>Methods: </strong>This study was carried out using experimental animals, a total of 27 rats were divided into 3 large groups, each group consisted of 9 rats, where group 1 was the control based ointment, group 2 was the comparison group (ointment T®) and group 3 was treated with 10% concentration of meniran leaf ethyl acetate subfraction ointment. Each group was observed and measured for three parameters, namely, percentage of wound healing, epithelialization time, and hydroxyproline levels.</p> <p><strong>Results: </strong>From the results of data analysis using one-way (ANOVA) followed by the duncan test (SPSS 23.0) for epithelialization time and hydroxyproline levels, the results showed that 10% concentration of meniran leaf ethyl acetate subfraction ointment, the comparison group (T® ointment) and the control based group with the treatment group on the parameters of epithelialization time and hydroxyproline have levels significant of (p <0.05)</p> <p><strong>Conclusions: </strong>It can be concluded that the ethyl acetate subfraction ointment of meniran leaves with a concentration of 10% is effective in the healing process of the excision wound.</p> <p><strong>Keywords</strong></p> <p><em>Phyllanthus niruri </em>L, wound healing , epithelialization, hidroksiprolin</p>
Morphological changes of zebrafish macrophages during wound healing
<p>Tg(mpeg1:gal4/UAS:Kaede) larvae with mosaic expression of Kaede protein in macrophages were amputated at 3 dpf and imaged using high resolution Spinning Disk microscopy between 8 to 13 h,every 2.5 min (C) Quantification of perimeter (upper graph) and circularity value (lower graph) for individual macrophages present at the wound, during a time lapse sequence from 8 hpA to 13 hpA every 2.5 min. For quantification, we used automated image analysis, the image segmentation was carried out from 8 to 13 hpA. At first, the images were filtered by using space-time filtering that keeps the temporal coherence of moving macrophages (Sarti et al., 1999). Then, the filtered images were segmented by a combination of the local Otsu method (Otsu, 1979; Saddami et al., 2019) and (Park et al., unpublished) and the subjective surface segmentation (SUBSURF) method (Sarti et al., 2000) where the binarized images from the local Otsu method were considered as an initial condition of the SUBSURF equation (Park et al., 2023). Trajectories of macrophages in segmented images were reconstructed based on automatic cell tracking (Park et al., 2023), and shape descriptors (perimeter and circularity) were measured. Refernces: Sipka T, Park SA, Ozbilgic R, Balas L, Durand T, Mikula K, Lutfalla G, Nguyen-Chi M. (2022). Macrophages undergo a behavioural switch during wound healing in zebrafish. Free Radical Biology and Medicine 192:200–212.<br> doi:10.1016/j.freeradbiomed.2022.09.021 and Park SA, Sipka T, Kriva Z, Lutfalla G, Nguyen-Chi M, Mikula K. (2023). Segmentation-based tracking of macrophages in 2D+time microscopy movies inside a living animal. Computers in Biology and Medicine 153, 106499. doi: 10.1016/j.compbiomed.2022.106499</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.