FY2019 NIH awards · Principal investigators
Internal Medicine at Weill Cornell Medicine
New York, NY
- NIH names only the principal investigators on an award, so this page lists only them. The department is the award's: it is where ScienceDex counts the award, not a list of the department's members.
- These are the awards in the Internal Medicine row of the Weill Cornell Medicine page.
Leads a grant in this department
96 contact PIs of these awards, by the funding they lead. Other principal investigators on an award are listed with it and under Co-investigators.
Imperato-McGinley, Julianne L
Leads 1 award · $7,431,841
- 5UL1TR002384-03Department: NIH department codeClinical and Translational Science Center$7,431,841award amount
Jones, R. Brad
Leads 1 award · $5,555,460
- 5UM1AI126617-04Department: NIH department codeBELIEVE: Bench to Bed Enhanced Lymphocyte Infusions to Engineer Viral Eradication$5,555,460award amount
Gulick, Roy M.
Leads 1 award · $4,802,563
- 5UM1AI069419-13Department: NIH department codeWeill Cornell Medical College-New Jersey Medical School Clinical Trials Unit$4,802,563award amount
Czaja, Sara J
Leads 4 awards · $2,902,537
- 5P01AG017211-21Department: NIH department codeCenter for Research and Education on Aging and Technology Enhancement - CREATE IV$1,527,245award amount
- 5R01AG054009-04Department: NIH department codeA non-pharmacological intervention for patients with Alzheimer s disease and family caregivers$745,798award amount
- 5R01AG053163-04Department: NIH department codeA Personalized Health Behavior System to Promote Well-Being in Older Adults$587,119award amount
- 3P01AG017211-20S2Department: NIH department codeCenter for Research and Education on Aging and Technology Enhancement - CREATE IV$42,375award amount
Guo, Chun-Jun
Leads 1 award · $2,542,500
- 1DP2HD101401-01Department: NIH department codeAn integrative and generalizable approach to modulate microbiota small molecules in the host$2,542,500award amount
Han, Meilan K
Leads 1 award · $2,062,326
- 5R01HL136682-03Department: NIH department codeThe CAPTURE Study: Validating a unique COPD screening tool in primary care$2,062,326award amount
Giuliano, Anna R.
Leads 1 award · $1,801,861
- 1U54CA242639-01Department: NIH department codePartnership for Prevention of HPV-Associated Cancers in People Living with HIV: Brazil, Mexico, and Puerto Rico$1,801,861award amount
Cohen, David E.
Leads 4 awards · $1,767,056
- 5R37DK048873-25Department: NIH department codeRegulation of Hepatic Lipid and Glucose Metabolism by PC-TP/StarD2$596,301award amount
- 5R01DK056626-21Department: NIH department codePhospholipid-Mediated Metabolic Control in the Liver$526,618award amount
- 5R01DK103046-06Department: NIH department codeThem1-Mediated Metabolic Regulation and Pathogenic Role in NAFLD$480,908award amount
- 1T32DK116970-01A1Department: NIH department codeMultidisciplinary Research Training in Gastroenterology and Hepatology$163,229award amount
Lipkin, Steven M
Leads 3 awards · $1,590,715
- 5U01CA233056-02Department: NIH department codeNeoantigen Vaccination for Lynch Syndrome Immunoprevention$717,507award amount
- 5R01CA231283-02Department: NIH department code(PQ1) Adaptive immune and microbial mechanisms regulating Lynch syndrome penetrance$485,477award amount
- 1R01CA227722-01A1Department: NIH department codeElucidating the Role of MALAT1 Somatic Driver Mutations in Colorectal Cancer$387,731award amount
Shaykhiev, Renat
Leads 3 awards · $1,547,790
- 1U01HL145561-01Department: NIH department codeThe Human Distal Airway Aging Project$700,290award amount
- 5R01HL123544-05Department: NIH department codeDefective FGFR2 Signaling in the Small Airway Basal Progenitor Cells in COPD$423,750award amount
- 5R01HL127393-04Department: NIH department codeAmphiregulin-driven COPD-relevant Remodeling of Human Airway Epithelium$423,750award amount
Artis, David
Leads 4 awards · $1,525,500
- 5R01AI074878-10Department: NIH department codeInnate immunity and inflammation following helminth infection$423,750award amount
- 5R01AI095466-07Department: NIH department codeRegulation and function of innate lymphoid cells in the gut$423,750award amount
- 5U01AI095608-10Department: NIH department codeInnate immune regulation of airway inflammation$423,750award amount
- 1R21AI142213-01Department: NIH department codeMicrobiota-dependent regulation of the gut-brain axis$254,250award amount
Sonnenberg, Gregory F
Leads 3 awards · $1,475,479
- 1R01AI145989-01Department: NIH department codeInterleukin-2 regulation of mucosal inflammation$543,366award amount
- 1R01AI143842-01Department: NIH department codeDefining a novel mechanism of mucosal healing$508,363award amount
- 5R01AI123368-04Department: NIH department codeImmune regulation of intestinal health and disease$423,750award amount
Blander, Julie Magarian
Leads 3 awards · $1,219,909
- 5R01AI123284-04Department: NIH department codeNon-Canonical Cross-presentation in Dendritic Cells Upon TAP Blockade$419,267award amount
- 5R01AI127658-05Department: NIH department codeNovel vita-vaccine formula combines safety of dead and efficacy of live vaccines$419,267award amount
- 5R01DK111862-03Department: NIH department codeRole of apoptosis in the intestinal epithelium during homeostasis and disease$381,375award amount
Pitt, Geoffrey S
Leads 2 awards · $1,111,328
- 2R01MH118934-06A1Department: NIH department codeMolecular and circuit defects underlying different SCN2A mutations and ASDs$643,410award amount
- 5R01HD090132-04Department: NIH department codeInvestigation of the roles for CaV1.2 in non-excitable tissue during development$467,918award amount
Hollenberg, Anthony N
Leads 2 awards · $1,075,350
- 1R01DK117940-01A1Department: NIH department codeThyroid Hormone Signaling in Human Hepatocytes$695,438award amount
- 5R01DK105029-05Department: NIH department codeThyroid Follicular Cell Development in Mice and Humans$379,912award amount
Fitzgerald, Daniel W
Leads 4 awards · $1,067,640
- 5R01HD091935-03Department: NIH department codeFANMI: Community Cohort Care for HIV-Infected Adolescent Girls in Haiti$591,524award amount
- 5D43TW010062-05Department: NIH department codeResearch Training Program in the Diagnosis, Treatment, and Prevention of AIDS-related MDR-TB in Haiti$290,429award amount
- 5K24AI098627-07Department: NIH department codeGlobal Health Research Training in HIV and Tuberculosis$183,687award amount
- 3D43TW010062-05S1Department: NIH department codeResearch Training Program in the Diagnosis, Treatment, and Prevention of AIDS-related MDR-TB in Haiti$2,000award amount
Choi, Augustine M
Leads 2 awards · $1,061,865
- 5R01HL132198-03Department: NIH department codeMetabolic dysfunction regulates mitophagy-dependent necroptosis in COPD$553,373award amount
- 5R01HL055330-21Department: NIH department codeInflammasomes: Regulation and Function in Acute Lung Injury$508,492award amount
Dow, Lukas Edward
Leads 2 awards · $1,024,140
- 1R01CA229773-01A1Department: NIH department codeIn Vivo Base Editing for Precision Oncology Models$646,960award amount
- 5R01CA222517-02Department: NIH department codeProgression, response, and resistance of RSPO fusion colorectal cancer$377,180award amount
Landau, Dan
Leads 2 awards · $1,005,413
- 1R01HL145283-01Department: NIH department codeThe role of DNA methylation modifiers in shaping the hematopoietic differentiation topology$530,668award amount
- 5R01CA229902-02Department: NIH department codeDefining Epidrivers of CLL Evolution in Response to Targeted Therapy$474,745award amount
Melnick, Ari M.
Leads 1 award · $986,490
- 5R35CA220499-02Department: NIH department codeTargeting Epigenetic Circuits in B-Cell Lymphomas$986,490award amount
Cantley, Lewis C
Leads 1 award · $986,489
- 5R35CA197588-04Department: NIH department codePhosphoinositides and Cancer Metabolism$986,489award amount
Martinez, Fernando J
Leads 1 award · $976,537
- 1UG3HL145266-01A1Department: NIH department code1/2 Prospective tReatment EffiCacy in IPF uSlng genOtype for Nac Selection (PRECISIONS) trial and Molecular Endophenotyping in Idiopathic Pulmonary Fibrosis and Interstitial Lung Diseases study$976,537award amount
Bajorin, Dean F.
Leads 1 award · $976,319
- 5KL2TR002385-03Department: NIH department codeInstitutional Career Development Core$976,319award amount
Kern, Lisa M
Leads 1 award · $905,251
- 5R01HL135199-03Department: NIH department codeHealthcare Fragmentation and Cardiovascular Outcomes$905,251award amount
Choi, Augustine M
Leads 2 awards · $860,928
- 5R01HL133801-03Department: NIH department codeNovel role of RIPK3-dependent necroptosis pathway in lung and kidney fibrosis$523,411award amount
- 5T32HL134629-02Department: NIH department codeMultidisciplinary Approach Training in Respiratory Research$337,517award amount
Fins, Joseph J.
Leads 1 award · $858,243
- 1RF1MH121378-01Department: NIH department codeCognitive Restoration: Neuroethics and Disability Rights$858,243award amount
Irvine, Darrell J
Leads 1 award · $838,922
- 1R01AI147845-01Department: NIH department codeTargeted delivery of cytopathicity enhancing agents, and co-ordination with shock and kill, to reduce HIV reservoirs$838,922award amount
Stout Delgado, Heather Winona
Leads 2 awards · $796,650
- 5R01AG052530-03Department: NIH department codeImpact of Heightened ER Stress on NLRP3 Activation in Aged Lung during Infection$423,750award amount
- 5R01AG056699-02Department: NIH department codeImpact of Heightened UPR Activation on Inflammasome Responses to Influenza and Secondary Streptococcus pneumoniae Infection in Aged Lung$372,900award amount
Levitan, Emily B
Leads 1 award · $721,635
- 5R01HL080477-13Department: NIH department codeREasons for Geographic And Racial Differences in Stroke- Myocardial Infarction-3$721,635award amount
Kiem, Hans-Peter
Leads 1 award · $706,493
- 5U01AI138329-02Department: NIH department codeEndothelial cell transplantation for multi-organ repair to counter radiation injury$706,493award amount
Weinsaft, Jonathan W.
Leads 1 award · $700,309
- 5R01HL128278-05Department: NIH department codeCMR Myocardial Tissue Based Prediction of Ischemic MR Revascularization Response$700,309award amount
Khurana, Ekta
Leads 3 awards · $694,095
- 5R01CA218668-02Department: NIH department codeComputational Methods for Identifying Non-coding Cancer Drivers$483,437award amount
- 3R01CA218668-02S1Department: NIH department codeDeep learning-based approach to identify non-coding cancer drivers that alter chromatin conformation$113,967award amount
- 3R01CA218668-02S2Department: NIH department codePredicting the functional impact of non-coding mutations using patient-specific gene regulatory networks$96,691award amount
Rafii, Shahin
Leads 1 award · $687,197
- 5R01HL139056-02Department: NIH department codeMolecular Determinants of endothelial transition into engraftable hematopoietic cells$687,197award amount
Peck, Robert N
Leads 2 awards · $679,418
- 5R01MH118107-02Department: NIH department codeReducing Post-Hospital Mortality in HIV-Infected Adults in Tanzania$541,907award amount
- 5K01TW010281-05Department: NIH department codeHypertension in HIV-Infected Tanzanians: Time Course and Pathogenesis$137,511award amount
Iliev, Iliyan Dimitrov
Leads 2 awards · $635,625
- 5R01DK113136-03Department: NIH department codeCommensal fungal communities in the regulation of immunity and intestinal inflammation.$381,375award amount
- 1R21AI146957-01Department: NIH department codeInvestigation of commensal bacteria-produced metabolites with activity towards mycobiota.$254,250award amount
McNairy, Margaret Leighton
Leads 1 award · $633,425
- 5R01HL143788-02Department: NIH department codeA longitudinal cohort study to evaluate cardiovascular risk factors and disease in Haiti$633,425award amount
Prigerson, Holly Gwen
Leads 1 award · $623,571
- 5R35CA197730-05Department: NIH department codePsychosocial Approaches to Better Understanding & End-Stage Cancer Care (PROTECT)$623,571award amount
Kirkman, Laura
Leads 1 award · $599,534
- 1R01AI146153-01Department: NIH department codeRole of Translesional Polymerases in Genome Diversification of the Malaria Parasite$599,534award amount
Andersen, Olaf S.
Leads 1 award · $585,840
- 5TL1TR002386-03Department: NIH department codeJ NRSA Training Core$585,840award amount
Pillemer, Karl A
Leads 1 award · $568,927
- 2P30AG022845-16Department: NIH department codeCornell Roybal Center-Translational Research Institute on Pain in Lather Life$568,927award amount
Zhou, Qiao Joe
Leads 1 award · $534,072
- 7R01DK106253-04Department: NIH department codeReprogram gastric tissue to functional insulin-secreting cells$534,072award amount
Cruz, Conrad Russell Young
Leads 1 award · $510,760
- 5R33AI122391-04Department: NIH department codeEngineered CTL with Inducible Ab Secretion; a Tripartite attack on HIV Reservoirs$510,760award amount
Schwartz, Robert E
Leads 2 awards · $506,393
- 1R01CA234614-01A1Department: NIH department codeModeling Hepatoblastoma using pluripotent stem cell derived hepatocyte-like cells$379,268award amount
- 5R03DK117252-02Department: NIH department codeIdentification of Hepatitis B Virus permissiveness factors$127,125award amount
Elemento, Olivier
Leads 1 award · $489,103
- 5R01CA228512-02Department: NIH department codeA novel, short isoform of the +TIP microtubule (MT) binding protein CLIP170 confers taxane resistance by obstructing the MT pore.$489,103award amount
Brown, Kristy A.
Leads 1 award · $487,639
- 5R01CA215797-03Department: NIH department codeObesity Increases Breast Cancer Penetrance in BRCA Mutation Carriers: A Role for Local and Systemic Factors$487,639award amount
Longman, Randy S
Leads 2 awards · $464,846
- 5R01DK114252-02Department: NIH department codeHost-Microbiota Interactions in Crohn's Disease-associated Spondyloarthritis$380,096award amount
- 5R03DK111852-02Department: NIH department codeInvestigating microbial regulation of intestinal mononuclear phagocyte production of TL1A in ILC3-dependent barrier immunity$84,750award amount
Varmus, Harold E
Leads 1 award · $448,281
- 5U01CA224326-02Department: NIH department codeStudies of the initiation and progression of small cell lung cancer using cells derived by differentiation from human pluripotent stem cells$448,281award amount
Jones, R. Brad
Leads 1 award · $423,750
- 5R01AI131798-03Department: NIH department codeCTL-Mediated Elimination of Replication Competent vs. Defective HIV Proviruses from Natural Latent Reservoirs: Roles of Antigen Specificity and Functional Characteristics$423,750award amount
Lo, James C
Leads 1 award · $423,750
- 1R01DK121844-01Department: NIH department codeAn Obesity-Induced Kinase that Regulates Adipose Homeostasis and Metabolic Diseases$423,750award amount
De Jong, Ype Peter
Leads 1 award · $381,375
- 1R01AA027327-01A1Department: NIH department codeModeling alcohol toxicity in human hepatocytes$381,375award amount
Nixon, Douglas F
Leads 1 award · $371,373
- 5R01CA206488-04Department: NIH department codeHIV induced anti-cancer HERV immunity in prostate, breast and colon cancers$371,373award amount
Prigerson, Holly Gwen
Leads 1 award · $351,555
- 5T32AG049666-04Department: NIH department codeThe Weill Cornell Medical College Research Training Program in Behavioral Geriatrics$351,555award amount
Rhee, Kyu Y
Leads 1 award · $334,714
- 1R25AI140472-01A1Department: NIH department codeTri-I Training Program in Metabolomics$334,714award amount
Alonso, Laura C
Leads 1 award · $314,436
- 7R01DK114686-04Department: NIH department codeATF6 and the Beta Cell$314,436award amount
Christini, David J.
Leads 1 award · $290,411
- 1R25GM130494-01Department: NIH department codeWeill Cornell Initiative for Maximizing Student Development$290,411award amount
Blenis, John
Leads 1 award · $282,993
- 5T32CA203702-03Department: NIH department codeMolecular and Translational Oncology Research$282,993award amount
Burd, Irina
Leads 1 award · $269,192
- 1R21HD099000-01Department: NIH department codePlacental determinants of neonatal immune function in maternal HIV infection$269,192award amount
Cloonan, Suzanne M
Leads 1 award · $249,000
- 5R00HL125899-05Department: NIH department codeMitochondrial Iron metabolism in Chronic Obstructive Pulmonary Disease$249,000award amount
Phongtankuel, Veerawat
Leads 1 award · $237,075
- 1K76AG059997-01A1Department: NIH department codeDeveloping and piloting a multi-component technology-based care intervention to address patient symptoms and caregiver burden in home hospice$237,075award amount
Epstein, Andrew
Leads 1 award · $231,699
- 1R21NR018693-01Department: NIH department codeCommunicating the Gist of Prognosis: Giving Information Simply and Transparently ("GIST") in Advanced Cancer$231,699award amount
McConnell, Kelly
Leads 1 award · $221,822
- 5R21CA224874-02Department: NIH department codeA communication-based intervention for advanced cancer patient-caregiver dyads to increase engagement in advance care planning and reduce caregiver burden$221,822award amount
Dupnik, Kathryn M
Leads 1 award · $192,780
- 5K23AI131913-02Department: NIH department codeHost susceptibility to Mycobacterium tuberculosis recurrence in HIV-infected people$192,780award amount
Mathad, Jyoti S
Leads 1 award · $192,780
- 5K23AI129854-03Department: NIH department codeEffect of pregnancy and HIV on the development of tuberculosis$192,780award amount
Singh, Parmanand
Leads 1 award · $191,340
- 5K23HL138299-03Department: NIH department codeImpact of Aortic Wall Inflammation and Stiffness on Thoracic Aortic Growth in Marfan Syndrome$191,340award amount
Satlin, Michael Joseph
Leads 1 award · $191,015
- 5K23AI114994-05Department: NIH department codeRapid Identification of Neutropenic Patients at High Risk of CRE Bacteremia$191,015award amount
Lee, John Richard
Leads 1 award · $190,358
- 5K23AI124464-04Department: NIH department codeGut Microbiome, Acute Rejection, and Tacrolimus Dosing in Kidney Transplantation$190,358award amount
Vorkas, Charles Kyriakos
Leads 1 award · $184,264
- 5K08AI132739-02Department: NIH department codeThe role of Mucosal-associated invariant T (MAIT) cells during the innate immune response to Mycobacterium tuberculosis$184,264award amount
Giannakakou, Paraskevi
Leads 1 award · $178,800
- 5R21CA216800-02Department: NIH department codeBiomarkers of taxane chemotherapy response/resistance in prostate cancer$178,800award amount
Reid, Manney Carrington
Leads 1 award · $176,244
- 5K24AG053462-04Department: NIH department codeReid Aging and Pain Research Training Program$176,244award amount
Kapadia, Shashi
Leads 1 award · $172,410
- 1K01DA048172-01Department: NIH department codeIntegrated Care for Hepatitis C: Current Uptake & Impact on Future Treatment$172,410award amount
Shen, Megan Johnson
Leads 1 award · $172,260
- 5K07CA207580-03Department: NIH department codeCulturally Competent Communication Intervention to Improve Latinos' Engagement in Advance Care Planning$172,260award amount
Saito, Kohta
Leads 1 award · $172,006
- 1K08AI139360-01A1Department: NIH department codeIdentifying the Molecular Target of Two Novel Compounds Active Against Non-replicating Mycobacterium tuberculosis and Delineating the Role of the Putative Target, InhA, in Non-replicating States$172,006award amount
Reed, Hasina Outtz
Leads 1 award · $171,936
- 1K01HL145365-01Department: NIH department codeThe Pulmonary Lymphatics in Inflammation and Disease$171,936award amount
Sharaf, Ravi
Leads 1 award · $171,936
- 7K07CA216326-02Department: NIH department codeGene Dependent Cancer Risk and Optimal Cancer Prevention Strategies in Lynch Syndrome$171,936award amount
Navarro-Millán, Iris Y
Leads 1 award · $171,180
- 5K23AR068449-03Department: NIH department codeOptimization of hyperlipidemia management among patients with rheumatoid arthritis: A patient-centered intervention development$171,180award amount
Kim, Jiwon
Leads 1 award · $169,740
- 5K23HL140092-02Department: NIH department codeAdvanced CMR Tissue-Based Prediction of Right Ventricular Dysfunction and Revascularization Response$169,740award amount
Cho, Soo Jung
Leads 1 award · $165,780
- 5K08HL138285-03Department: NIH department codeGLUT1-dependent glycolysis regulates age-susceptible lung fibrosis$165,780award amount
Goncalves, Marcus Dasilva
Leads 1 award · $149,682
- 5K08CA230318-02Department: NIH department codeThe Role of Hypoketonemia in the Cancer Anorexia-Cachexia Syndrome$149,682award amount
Riffin, Catherine
Leads 1 award · $126,090
- 1K01AG061275-01Department: NIH department codeDeveloping a Screening Protocol for Family Caregivers of Older Persons with and without Dementia Seen in Primary Care$126,090award amount
Spellman, Timothy
Leads 1 award · $103,628
- 5K99MH117271-02Department: NIH department codePrefontal Microcircuits Underlying Cognitive Flexibility$103,628award amount
Ersoy, Baran
Leads 1 award · $84,750
- 1R03DK117247-01A1Department: NIH department codeAcot9 Promotes Lipotoxicity$84,750award amount
Chen, Joyce Huanhuan
Leads 1 award · $83,988
- 1K99CA226353-01A1Department: NIH department codeInvestigation of sub-lineages in pulmonary neuroendocrine cells and identification of the cells of origin of small cell lung cancer$83,988award amount
Bessman, Nicholas J.
Leads 1 award · $65,158
- 5F32AI124517-03Department: NIH department codeThe molecular basis of host-microbiota interactions$65,158award amount
Lynch, Charles Joseph
Leads 1 award · $63,104
- 1F32MH120989-01Department: NIH department codeTargeting salience network dysfunction in depression with individualized brain network mapping and TMS$63,104award amount
Fiers, William D
Leads 1 award · $61,610
- 1F32DK120228-01Department: NIH department codeRegulation of the mycobiota and intestinal inflammation via production of antifungal metabolites by commensal bacteria$61,610award amount
Mukhtar, Eiman A
Leads 1 award · $61,610
- 5F32CA220988-03Department: NIH department codeIdentification of AR-variant nuclear import pathways in prostate cancer and elucidation of the molecular mechanisms underlying clinical taxane resistance$61,610award amount
Baksh, Sanjeethan
Leads 1 award · $50,016
- 5F31CA236465-02Department: NIH department codeDissecting the role of serine metabolism in tumor initiating stem cells$50,016award amount
Herre, Margaret R.
Leads 1 award · $50,016
- 5F30DC017658-02Department: NIH department codeHormone regulation of olfactory neuron function in the Zika vector Aedes aegypti$50,016award amount
Hurwitz, Brian S.
Leads 1 award · $50,016
- 1F30CA236239-01Department: NIH department codeThe integrated stress response in stem cells and cancer$50,016award amount
Navrazhina, Kristina
Leads 1 award · $46,765
- 1F30CA236302-01Department: NIH department codeInvestigating the role of nucleotide metabolism and AMPK signaling in melanoma metastasis$46,765award amount
Pelham-Webb, Bobbie
Leads 1 award · $46,765
- 1F30HD097926-01Department: NIH department codeThe Role of Mitotic Bookmarking in the Molecular Resetting of the Pluripotent Stem Cell Identity$46,765award amount
Weiss, Joshua M.
Leads 1 award · $46,765
- 1F30CA236442-01Department: NIH department codeInvestigating the Role of Adipocyte Lipolysis in Melanoma Progression$46,765award amount
Grigg, John Benjamin
Leads 1 award · $45,016
- 1F31AI138389-01A1Department: NIH department codeTolerogenic and pathologic interactions between ILCs and T cells in autoimmunity$45,016award amount
Ngo, Bryan D
Leads 1 award · $45,016
- 5F99CA234950-02Department: NIH department codeMechanisms and Models of Chromosomal Instability in Cancer$45,016award amount
Sridharan, Ramya
Leads 1 award · $45,016
- 1F31CA232665-01A1Department: NIH department codeImproving targeted therapy in KRAS mutant lung cancers$45,016award amount
Naseri, Nima Nick
Leads 1 award · $43,807
- 5F31NS098623-03Department: NIH department codeDisease causing mutations in cysteine string protein-alpha disrupt SNARE-dependent lysosomal exocytosis$43,807award amount