Cancer Model Systems (MDLS): NBL and Pediatric Preclinical Testing Program (PPTP)

The TARGET Pan-cancer Model Systems (MDLS) were developed to study the mechanisms of tumor development and response to treatments of high-risk or hard-to-treat childhood cancers. MDLS includes acute leukemia cell lines and xenografts with matched primary and/or relapsed tumor information, neuroblastoma cell lines and xenografts with matched controls, kidney tumor cell lines, normal brain tissues, and embryonic stem cell lines that were sequenced for some TARGET disease projects.