RB1 Loss Triggers Dependence on ESRRG in Retinoblastoma
Retinoblastoma (Rb) is a deadly childhood eye cancer that is classically initiated by inactivation of the RB1 tumor suppressor. Clinical management continues to rely on nonspecific chemotherapeutic agents that are associated with treatment resistance and toxicity. Here, we analyzed whole exomes from primary Rb tumors to identify novel Rb dependencies. Several recurrent genomic aberrations implicate estrogen-related receptor gamma (ESRRG) in Rb pathogenesis. ESRRG is an essential mediator of hypoxic adaptation and cell survival in retinoblastoma, representing a promising new therapeutic target.
ShareScore
8/100
Overall dataset sharing score
Score breakdown
These five areas show where the dataset supports — or may limit — practical reuse.
- Stewardship
- 4
- Harmonization
- 4
- Access
- 0
- Reuse readiness
- 0
- Engagement
- 0
Dataset details
- Repository
- CCDI Data Catalog
- Published
- Not reported
- License
- Not reported
- DOI
- Not reported
Scored with release 0.9.0
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