Exosomes mediate intercellular transfer of non-autonomous tolerance to proteasome inhibitors in mixed-lineage leukemia

<p><strong>Supplementary Materials</strong></p> <p>Figure S1. PI resistance is reversible in MLL cells.</p> <p>Figure S2. PI-treated cell-derived exosomes induce cell cycle arrest and PI resistance in SEM cells.</p> <p>Figure S3. Unsupervised hierarchical clustering heatmap of differentially expressed proteins in RS4;11-Nexo- or RS4;11-Rexo-treated RS4;11 cells.</p> <p>Figure S4. Integrated network nodes and edges related to &ldquo;upstream&rdquo; exosomal proteins.</p> <p>Figure S5. Integrated network nodes and edges related to &ldquo;downstream&rdquo; genes in the transcriptome profile of recipient cells.</p> <p>Figure S6. Potential therapeutic targets related to exosomal regulatory proteins.</p> <p>Figure S7. TieDIE integration network nodes and edges related to the cell cycle pathway.</p> <p>Figure S8. TieDIE integration network nodes and edges related to the stemness pathway.</p> <p>Figure S9. The original western blot images in this manuscript.</p> <p>Table S1. Differentially expressed proteins in exosomes.</p> <p>Table S2. Nodes of the TieDIE integrated network.</p> <p>Table S3. The exosomal regulatory proteins and the corresponding drugs or compounds.</p>