Dataset related to article "Reirradiation of Locally Recurrent Prostate Cancer With Volumetric Modulated Arc Therapy."

<p>PURPOSE:</p> <p>This study explores the efficacy and safety of reirradiation with modern radiation therapy techniques in patients previously irradiated for prostate cancer and affected by local relapse of disease.</p> <p>METHODS AND MATERIALS:</p> <p>Patients affected by previously irradiated prostate cancer were enrolled in this reirradiation study if they had a biochemical relapse and a ¹¹C-choline positron emission tomography scan revealing the presence of a local recurrence of disease. Reirradiation consisted of a stereotactic treatment delivered by image guided radiation therapy-volumetric modulated arc therapy with flattening filter-free technology in 5 daily fractions.</p> <p>RESULTS:</p> <p>Twenty-three patients underwent reirradiation to the prostate, prostatic bed, or prostate and local recurrence. Re-treatment consisted of a median total dose of 25&nbsp;Gy in 5 fractions. A biochemical response was observed in all cases. Acute toxicity was mainly genitourinary (GU) grade 1 to 2 (n&nbsp;=&nbsp;13; 56.5%). One patient (4.3%) had grade 3 hematuria. A grade 1 GU late toxicity was registered in 4 patients (17.4%) and grade 3 in 1 patient (4.3%, urethral obstruction). Gastrointestinal toxicity was negligible. Regression analysis showed that only a short elapsed time in months from primary radiation therapy was significantly correlated with acute GU toxicity. After a median follow-up of 33&nbsp;months (range, 5-58&nbsp;months), the median biochemical recurrence-free survival was 19&nbsp;months, and the 2-year biochemical recurrence-free survival (BRFS) was 41.7%. Median local control was 30&nbsp;months; the 2-year local control rate was 58.1%.</p> <p>CONCLUSIONS:</p> <p>Reirradiation of patients with prostate cancer who underwent previous radiation therapy is a valuable option that can be safely considered to delay the beginning of hormonal treatment.</p>