Dataset related to article "Neutrophils Driving Unconventional T Cells Mediate Resistance against Murine Sarcomas and Selected Human Tumors"

<p>Neutrophils are a component of the tumor microenvironment and have been predominantly associated with cancer progression. Using a genetic approach complemented by adoptive transfer, we found that neutrophils are essential for resistance against primary 3-methylcholantrene-induced carcinogenesis. Neutrophils were essential for the activation of an interferon-&gamma;-dependent pathway of immune resistance, associated with polarization of a subset of CD4^- CD8^- unconventional &alpha;&beta; T&nbsp;cells (UTC_{&alpha;&beta;}). Bulk and single-cell RNA sequencing (scRNA-seq) analyses unveiled the innate-like features and diversity of UTC_{&alpha;&beta;} associated with neutrophil-dependent anti-sarcoma immunity. In selected human tumors, including undifferentiated pleomorphic sarcoma, CSF3R expression, a neutrophil signature and neutrophil infiltration were associated with a type 1 immune response and better clinical outcome. Thus, neutrophils driving UTC_{&alpha;&beta;} polarization and type 1 immunity are essential for resistance against murine sarcomas and selected human tumors.</p>