Dataset related to the article "Reduced Cardiorenal Function Accounts for Most of the In-Hospital Morbidity and Mortality Risk Among Patients With Type 2 Diabetes Undergoing Primary Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction"

<p>This record contains raw data related to the article &quot;Reduced Cardiorenal Function Accounts for Most of the In-Hospital Morbidity and Mortality Risk Among Patients With Type 2 Diabetes Undergoing Primary Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction&quot;</p> <p><strong>ABSTRACT</strong>&nbsp; ST-segment elevation myocardial infarction (STEMI) patients with diabetes mellitus<br> (DM) have higher in-hospital mortality than those without. Since cardiac and renal<br> functions are the main variables associated with outcome in STEMI, we hypothesized<br> that this prognostic disparity may depend on a higher rate of cardiac and<br> renal dysfunction in DM patients.<br> RESEARCH DESIGN AND METHODS<br> We retrospectively analyzed 5,152 STEMI patients treated with primary angioplasty.<br> Left ventricular ejection fraction (LVEF) and estimated glomerular filtration rate<br> (eGFR) were evaluated at hospital admission. The primary end point was in-hospital<br> mortality. A composite of in-hospital mortality, cardiogenic shock, and acute kidney<br> injury was the secondary end point.<br> RESULTS<br> There were 879 patients (17%) with DM. The incidence of LVEF &pound;40% (30% vs. 22%),<br> eGFR &pound;60 mL/min/1.73m2 (27% vs. 18%), or both (12% vs. 6%) was higher (P &lt; 0.001<br> for all comparisons) inDMpatients. In-hospital mortality was higher inDMpatients<br> than in non-DM patients (6.1% vs. 3.5%; P = 0.002), with an unadjusted odds ratio<br> (OR) of 1.81 (95% CI 1.31&ndash;2.49; P &lt; 0.001). However, DM was no longer associated<br> with an increased mortality risk after adjustment for cardiac and renal function (OR<br> 1.03, 95% CI 0.68&ndash;1.56; P = 0.89). A similar behavior was observed for the secondary<br> end point, with an unadjusted OR for DM of 1.52 (95% CI 1.25&ndash;1.85; P &lt; 0.001) and<br> an OR after adjustment for cardiac and renal function of 1.07 (95% CI 0.85&ndash;1.36;<br> P = 0.53).<br> CONCLUSIONS<br> The study indicates that the increased in-hospital mortality and morbidity of DM<br> patients with STEMI is mainly driven by their underlying cardiorenal dysfunction.</p>