Dataset related to the article "High sensitivity C-reactive protein and acute kidney injury in patients wit acute myocardial infarction: a prospective observational study"

<p>This record contains raw data related to the article &quot;High sensitivity C-reactive protein and acute kidney injury in patients wit acute myocardial infarction: a prospective observational study&quot;</p> <p><strong>Abstract:</strong> Background. Accumulating evidence suggests that inflammation plays a key role in acute<br> kidney injury (AKI) pathogenesis. We explored the relationship between high-sensitivity C-reactive<br> protein (hs-CRP) and AKI in acute myocardial infarction (AMI). Methods. We prospectively included<br> 2,063 AMI patients in whom hs-CRP was measured at admission. AKI incidence and a clinical<br> composite of in-hospital death, cardiogenic shock, and acute pulmonary edema were the study<br> endpoints. Results. Two-hundred-thirty-four (11%) patients developed AKI. hs-CRP levels were<br> higher in AKI patients (45 87 vs. 16 41 mg/L; p &lt; 0.0001). The incidence and severity of AKI, as well<br> as the rate of the composite endpoint, increased in parallel with hs-CRP quartiles (p for trend &lt;0.0001<br> for all comparisons). A significant correlation was found between hs-CRP and the maximal increase<br> of serum creatinine (R = 0.23; p &lt; 0.0001). The AUC of hs-CRP for AKI prediction was 0.69 (p &lt; 0.001).<br> At reclassification analysis, addition of hs-CRP allowed to properly reclassify 14% of patients when<br> added to creatinine and 8% of patients when added to a clinical model. Conclusions. In AMI,<br> admission hs-CRP is closely associated with AKI development and severity, and with in-hospital<br> outcomes. Future research should focus on whether prophylactic renal strategies in patients with<br> high hs-CRP might prevent AKI and improve outcome.</p>