Dataset related to the article "Iron deficiency in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention"

<p>This record contains raw data related to the article &quot;Iron deficiency in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention&quot;</p> <p><strong>ABSTRACT</strong> Background: Iron deficiency (ID) is a known co-morbidity and a potential therapeutic target in heart failure.<br> Whether ID is frequent also in ST-segment elevation acute myocardial infarction (STEMI) patients and is associated<br> with worse in-hospital outcomes has never been evaluated.<br> Methods: We defined ID as a serum ferritin b 100 &mu;g/L or transferrin saturation b 20% at hospital admission.We<br> assessed the association between ID and the primary endpoint (a composite of in-hospital mortality and Killip<br> class &ge; 3). We explored the potential association between ID, circulating cell-free mitochondrial DNA<br> (mtDNA), and cardiac magnetic resonance (CMR) parameters.<br> Results: Four-hundred-twenty STEMI patients undergoing primary percutaneous coronary intervention (pPCI)<br> were included. Of them, 237 (56%) had ID. They had significantly higher admission high-sensitivity troponin<br> and mtDNA levels as compared to non-ID patients (145 &plusmn; 35 vs. 231 &plusmn; 66 ng/L, P b 0.001; 917 [404&ndash;1748] vs.<br> 1368 [908&ndash;4260] copies/&mu;L; P b 0.003, respectively). A lower incidence of the primary endpoint (10% vs. 18%, P<br> =0.01) was observed in ID patients (adjusted OR 0.50 [95% CI 0.27&ndash;0.93]; P=0.02). At CMR (n=192), ID patients<br> had a similar infarct size (21&plusmn;18 vs. 21&plusmn;19 g; P=0.95), but a higher myocardial salvage index (0.56&plusmn;<br> 0.30 vs. 0.43 &plusmn; 0.27; P = 0.002), and a smaller microvascular obstruction extent (3.6 &plusmn; 2.2 vs. 6.9 &plusmn; 3.9 g; P b<br> 0.001).<br> Conclusions: Iron deficiency is frequent in STEMI patients, it is coupled with mitochondrial injury, and, paradoxically,<br> with a better in-hospital outcome. This unexpected clinical result seems to be associated with a smaller<br> myocardial reperfusion injury. The mechanisms underlying our findings and their potential clinical implications<br> warrant further investigation.</p>