Systematic review data of whole grains versus placebo or refined grains on cardiovascular disease risk factors.

<p class="Body"><span>This dataset comprises data extracted 29 publications which were included in a systematic review and meta-analysis of randomised controlled trials which compared whole grain versus refined grain dietary intake on cardiovascular disease risk factors. There were 80 cardiovascular disease risk factor outcome measures considered in the review. Data were extracted by one investigator and checked for accuracy twice. Study characteristics were extracted, including study design, sample population, and details of the intervention and control conditions. Outcome data were extracted for the intervention and comparator groups were baseline, change, and follow-up variables, variable units, and statistical significance over time and between groups. Adverse events were also recorded. The 29 included studies measured and reported on 40 outcomes. Extracted outcomes can be grouped as haemodynamics (reported by 12 studies), body composition (15 studies), blood lipids (18 studies), glycaemic and/or insulin markers (19 studies), inflammatory markers (21 studies), oxidative stress markers (6 studies), and cardiovascular comorbidity incidence (2 studies). Rigorous analysis, including meta-regression, may be carried out using this data to evaluate the cause and effect relationship of whole grains on cardiovascular risk by considering confounding variables on pooled outcomes. </span></p>