Rat BAT Xenotransplantation Recovers the Fertility and Metabolic Health of PCOS Mice

<p><strong>Supplementary dataset 1</strong></p> <p>This file&nbsp;contains datasets for all 230 overlapped DEGs (Fig. 6A and B) among&nbsp;RTM, MTM, and control group compared with the PCOS group in F0 model mice. It has two sheets: &quot;F0 up-regulated&nbsp;DEGs&quot; contained all DEGs that have significantly higher (|log2| &gt; 1) expression levels&nbsp;in RTM, MTM, and control group than PCOS group; &quot;F0 down-regulated&nbsp;DEGs&quot; contained all DEGs that have significantly lower (|log2| &gt; 1) expression level in RTM, MTM, and control group than PCOS group. For each gene, both FPKM of each repeat and the average FPKM of three repeats are shown.</p> <p><strong>Supplementary dataset 2</strong></p> <p>This file, corresponding to Fig. 7, contains 4 sheets of datasets&nbsp;for all DEGs that overlapped between human PCOS studies and corrent study. From left to right, in sheet 1, the datasets from column A-AB are for the DEGs in current study; the datasets from column AD-BL are for the DEGs in Lan et al (36). In sheet 2, the datasets from column A-AA are for the DEGs in our study; the datasets from column AC-AI are for the DEGs in Wissing et al (37).&nbsp;In sheet 3, the datasets from column A-AB are for the DEGs in our study; the datasets from column AD-AL are for the DEGs in Lu&nbsp;et al (38).&nbsp;In sheet 4, the datasets from column A-AB are for the DEGs in our study; the datasets from column AD-AG are for the DEGs in Kaur et al (39).&nbsp;For a clear distinguishment between our data and the reference data, column AC in sheet 1, column AB in sheet 2, column AC in sheet 3, and column AC in sheet 4 are&nbsp;left blank and highlighted in green; Two columns with title &quot;symbol&quot; and red typed in each sheet list all overlapping DEGs between our data and reference data.</p> <p><strong>Supplementary dataset </strong><strong>3</strong></p> <p>This file&nbsp;contains 4 sheets. Each sheet includes KEGG information&nbsp;for the DEGs that overlapped between human PCOS studies and current study.</p> <p><strong>Supplementary dataset </strong><strong>4</strong></p> <p>This dataset contains all 126 overlapped DEGs (Supplementary Fig. 6A and B) among&nbsp;RTM, MTM, and control group compared with the PCOS group in F1&nbsp;model mice. It has two sheets: &quot;F1 up-regulated&nbsp;DEGs&quot; contained all DEGs that have significantly higher (|log2| &gt; 1) expression level in RTM, MTM, and control group than in PCOS group; &quot;F1 down-regulated&nbsp;DEGs&quot; contained all DEGs that have significantly lower (|log2| &gt; 1) expression level in RTM, MTM, and control group than in PCOS group. For each gene, both FPKM of each repeat and the average FPKM of three repeats are shown.</p>