The transcriptomic response of murine thyroid to iodide overload and the role of the Nrf2 antioxidant system

<p>Wild-type and Nrf2(Nfe2l2) knockout male C57BL6J mice 3-4 months old were administred 0.05% NaI in their drinking water for 7 days. Control mice were administered regular drinking water. After this treatment mice were euthanized and thyroids were excised for RNA preparation and then for mRNA and miRNA RNAseq.&nbsp;</p> <p>The file titled &quot;metadata RNAseq mRNA thyroid&quot; contains the experimental information as well as the allocation of sample numbers to the relevant groups. Briefly,&nbsp;</p> <p>806 Knockout Iodide</p> <p>829 Wild type Iodide</p> <p>815 Knockout Control</p> <p>811 Knockout Control</p> <p>801 Knockout Iodide</p> <p>836 Wild type Control</p> <p>838 Wild type Control</p> <p>807 Knockout Iodide</p> <p>834 Wild type Control</p> <p>827 Wild type Iodide</p> <p>831 Wild type Iodide</p> <p>804 Knockout Iodide</p> <p>825 Wild type Iodide</p> <p>841 Wild type Control</p> <p>812 Knockout Control</p> <p>803 Knockout Iodide</p> <p>810 Knockout Control</p> <p>The fastq data have been uploaded. The ones with &quot;miRNA&quot; in their file name refer to miRNA sequencing. All the others refer to mRNA sequencing.</p>