zenodoopen
Lactate Increases Stemness of CD8+ T Cells to Augment Anti-Tumor Immunity
<p>The immunological role of lactate in antitumor immunity is not well understood. In this study, we report lactate treatment significantly augments antitumor efficacy of immune checkpoint blockade or T cell vaccine therapy in multiple tumor models. Single cell transcriptomics and flow cytometry analysis revealed an increased subpopulation of stem-like TCF-1-expressing CD8<sup>+</sup> T cells upon lactate treatment.</p>
ShareScore
40/100
Overall dataset sharing score
Score breakdown
These five areas show where the dataset supports — or may limit — practical reuse.
- Stewardship
- 4
- Harmonization
- 4
- Access
- 20
- Reuse readiness
- 8
- Engagement
- 4