Dataset related to article: "Time Course of Autonomic Symptoms in Postural Orthostatic Tachycardia Syndrome (POTS) Patients: Two-Year Follow-Up Results

<p>This record contains data related to article &quot;Time Course of Autonomic Symptoms in Postural Orthostatic Tachycardia Syndrome (POTS) Patients: Two-Year Follow-Up Results&quot;</p> <p>Postural orthostatic tachycardia syndrome (POTS) is a multifactorial condition capable of<br> chronically reducing the quality of life and the work ability of patients. The study aim was to assess<br> the burden of autonomic symptoms in a cohort of POTS patients over 2 years. Patients&rsquo; clinical profiles<br> were assessed by the 31-item Composite Autonomic Symptom Score questionnaire (COMPASS 31)<br> and a visual analog scale (VAS). One-way ANOVA for repeated measures followed by Dunnett&rsquo;s<br> post-hoc test were used to compare symptoms at baseline and at 1 and 2 years. Out of 42 enrolled<br> patients, 25 had a 1-year follow-up and 12 had a 2-year follow-up. At baseline, the reported burden<br> of autonomic symptoms was high (overall COMPASS 31 = 49.9 14.3 /100). Main complaints were<br> related to orthostatic intolerance according to both COMPASS 31 and VAS. Fourteen patients were<br> rendered inactive because of symptoms. At 1-year follow-up, a statistically significant improvement<br> in pupillomotor function and overall score was detected by the COMPASS 31. These findings were<br> confirmed at 2 years, together with a significant reduction in quality of life impairment, assessed<br> by VAS. However, these improvements did not change patients&rsquo; occupational status. Awareness of<br> POTS diagnosis, patient monitoring, and tailored therapies can help to improve patients&rsquo; condition.</p>