Metabolomics dataset to identify plasma biomarkers in mice with metabolically heterogeneous melanoma xenografts

<p>Tumor xenografts were generated in mice using BRAF mutant A375 and WM47, NRAS mutant WM3000, and WM3311 (BRAF, NRAS, NF-1 wildtype) human melanoma cells. Xenograft tumor and plasma samples obtained from melanoma-bearing and non-tumor mice were analyzed using the MxP&reg; Quant 500 kit in combination with the inhouse UHPLC-MS/MS-based acylcarnitine assay from Biocrates Life Sciences AG, Innsbruck, Austria. The data were used to characterize the metabolomes of human melanoma cell lines with different genetic background transplanted into mice in order to identify potential new biomarkers and targets for melanoma therapy.</p>