Mortality in an Italian nursing home during COVID-19 pandemic: correlation with gender, age, ADL, vitamin D supplementation, and limitations of the diagnostic tests

<p><strong>Introduction: </strong> The COVID-19 pandemic caused an increased mortality in nursing homes due to its quick spread and the age-related high lethality.</p> <p><strong>Results: </strong> We observed a two-month mortality of 40%, compared to 6.4% in the previous year. This increase was seen in both COVID-19 positive (43%) and negative (24%) residents, but 8 patients among those testing negative on the swab, tested positive on serological tests. Increased mortality was associated with male gender, older age, no previous vitamin D supplementation and worse &quot;activities of daily living (ADL)&quot; scores, such as Barthel index, Tinetti scale and S.OS.I.A.</p> <p><strong>Conclusion: </strong> Our data confirms a higher geriatric mortality due to COVID-19. Negative residents also had higher mortality, which we suspect is secondary to preanalytical error and a low sensitivity of the swab test in poorly compliant subjects. Male gender, older age and low scores on ADL scales (probably due to immobility) are risk factors for COVID-19 related mortality. Finally, mortality was inversely associated with vitamin D supplementation.</p> <p><strong>Design: </strong> In this observational study, we described the two-month mortality among the 157 residents (age 60-100) of a nursing home after Sars-CoV-2 spreading, reporting the factors associated with the outcome. We also compared the diagnostic tests for Sars-CoV-2.</p> <p>&nbsp; </p><p>https://pubmed.ncbi.nlm.nih.gov/33353888/</p> <p></p>