Time series of epileptic seizures in a 8yo male on a cannabidiol trial

<p>Time series of epileptic seizures in a 8yo male with idiopathic catastrophic epilepsy (probably of mitochondrial origin) in a cannabidiol (CBD) trial.</p> <p>The data are of <strong>observed seizures </strong>during each day by the patient&#39;s parents and caregivers and thus are not exact values for total daily seizure activity; the values in this dataset are best considered a lower bound. However, observation effort was essentially constant over the time series, so the data likely reflect overall trends even though precise daily seizure counts are not available.</p> <p>The time series includes a 21-day baseline period and a 36-day trial period. The CBD was administered via g-tube in an olive oil base. Dosage was approximately 7.5 mg/kg/day for two weeks, and approximately 8 mg/kg/day for three weeks.</p> <p>Each 1ml of oil contained 10.00mg of total CBD and 0.42mg of total THC, for a CBD:THC ratio of approximately 20:1 (analysis by HPLC).</p> <p><strong><em>Data Dictionary</em></strong></p> <ul> <li><strong>Date</strong>: YYYY-MM-DD</li> <li><strong>Tonic</strong>: tonic seizure count (http://www.epilepsy.com/learn/types-seizures/tonic-seizures)</li> <li><strong>Tonic-Clonic</strong>: tonic-clonic (aka &quot;grand mal&quot;) seizure count (http://www.epilepsy.com/learn/types-seizures/tonic-clonic-seizures)</li> <li><strong>Spasms</strong>: myoclonic seizure count (http://www.epilepsy.com/learn/types-seizures/myoclonic-seizures)</li> <li><strong>Total</strong>: total number of seizures (sum of above)</li> <li><strong>Notes</strong>: notes by parents</li> </ul>