Data set of CA1 pyramidal cell models using an intact whole hippocampus preparationV2

<p>The frequency-current (f-I) profiles and an example of rebound firing of pyramidal cells are presented. Four .abf files contain the&nbsp;f-I curve data for the respective cell (as labelled PYR1, PYR2, PYR3 and PYR4 for Pyramidal cell 1, Pyramidal cell 2, Pyramidal cell 3 and Pyramidal cell 4). &nbsp;That is, they contain the cell&#39;s response to the application of a series of depolarizing current steps of 1 s duration while the cells are held in current clamp, as well as the current clamp data itself. &nbsp;Each recording is 2 s total. &nbsp;Amplitudes of the input were increased incrementally with step sizes of 10 pA for PYR1, PYR3, and PYR4, and a step size of 25 pA for PYR 2.&nbsp;&nbsp;PYR1 first spikes on the 5th of 30 steps with 38.7 pA of depolarizing input. &nbsp;PYR2 first spikes on the 3rd of 13 steps with 1.2 pA of input. &nbsp;PYR3 first spikes on the 7th of 34 steps with 62.0 pA of input, and PYR4 first spikes on the 7th of 30 steps with 12.1 pA of input.&nbsp; In the .abf file labelled PYR5_rebound, an example of rebound firing of a pyramidal cell following hyperpolarizing input is given.&nbsp; While the cell was held at -52 mV in current clamp, as series of 1 s hyperpolarizing steps (10 steps, 25 pA increments) were used to record the post- hyperpolarization rebound spiking.&nbsp; For the figure showing this rebound spiking (Figure 1), the first two hyperpolarizing steps and the respective firing are shown.&nbsp; For visualization purposes, the spike artifact in the current clamp input trace was removed and replaced with the mean current in the Figure.</p>