iGEMME Missense Mutational Effect Predictions for Entire Human Proteome

<p>This dataset contains iGEMME single point mutation predictions of about ~19000 human proteins. In iGEMME predictions, only evolutionary data coming from multiple sequence alignment files is used.&nbsp;</p> <h2>Description of the data and file structure</h2> <p>This dataset contains iGEMME predictions for all human proteins.&nbsp;</p> <p>Data of each human protein is in a folder named after its uniprotID. Inside uniprotID folder, there is a subfolder called results that contain all input and output. An example results folder for uniprotID A0A0B4J245 will contain the following files:</p> <ol> <li> <p><strong>Raw igemme predictions (output file):</strong> A0A0B4J245_normPred_evolCombi_igemme.txt</p> </li> <li> <p><strong>Ranksorted (between 0-1) igemme predictions in csv format (output file):</strong> A0A0B4J245_normPred_evolCombiTransposedRanksorted_igemme.csv</p> </li> <li> <p><strong>Colabfold MSA file (input file):</strong> aliA0A0B4J245.fasta</p> </li> <li> <p><strong>JET2 file containing JET scores for each amino acid (output file) :</strong> A0A0B4J245_jet_igemme.res</p> </li> <li> <p><strong>Configuration file containing default parameters (output file):</strong> default.conf</p> </li> <li> <p><strong>Log file (output file):</strong> igemme.log</p> </li> </ol>