Supplementary Data for "Epigenetic mechanisms controlling human leukemia stem cells and therapy resistance"

<p><strong>We performed functional genomic profiling of diverse leukemias using label tracing techniques. We identified&nbsp;AML stem cell&nbsp;quiescence is defined by distinct promoter-centered chromatin and gene expression dynamics, and controlled by a novel&nbsp;transcription factor network, which is associated with disease persistence and chemotherapy resistance in multiple patients. </strong></p>