Dataset: Justify your disability! A simulated medical evaluation as a robust novel stress induction paradigm in chronic pain patients.

<p><span>Maladaptive stress responses may exacerbate chronic widespread pain (CWP) and deserve further investigations. Yet, existing stress induction paradigms lack relevance for individuals with this condition. Hence, we developed the Social Benefits Stress Test (SBST), adapted from the Trier Social Stress Test. <span>Instead of a job interview, the main task consists in justifying the inability to work.</span>&nbsp;</span></p> <p><span><span>Forty women with CWP in the context of hypermobile Ehlers-Danlos syndrome or hypermobility spectrum disorders were included. They underwent a 30-min baseline, the new stress task and a recovery period. The psychophysiological stress response was captured using self-reported stress ratings, salivary cortisol and &alpha;-amylase levels, as well as continuous physiological monitoring of heart rate variability (HRV) and electrodermal activity (EDA).</span></span><span> </span></p> <p><span>Compared to baseline, the analysis revealed&nbsp;</span><span>a significant and transient increase in stress ratings </span><span>during the stress task,</span><span> </span><span>associated with a peak in salivary biomarkers concentrations.</span><span> </span><span>The </span><span>HRV signal analysis showed a significant </span><span>decrease in high frequency power (HF), and </span><span>increases in heart rate,</span><span> </span><span>low frequency power (LF) and in LF/HF ratio. The EDA analysis revealed a significant increase in skin conductance level (SCL) tonic component and skin conductance response (SCR). Subjective </span><span>stress ratings positively correlated with changes in salivary biomarkers, LF/HF ratio and EDA outcomes</span><span>.</span></p> <p><span>The SBST induced a reproducible moderate stress response across subjective and physiological measures in a population of CWP patients, validating this task as a relevant experimental model of social stress in chronic pain. The SBST is a useful tool to study the relationship between stress and chronic pain.</span></p>