Dataset related to article "NKG2A expression identifies a subset of human Vδ2 T cells exerting the highest antitumor effector functions"

<p>This record contains data related to article &quot;NKG2A expression identifies a subset of human V&delta;2 T cells exerting the highest antitumor effector functions&quot;</p> <p>&nbsp;</p> <p>Human V&delta;2 cells are innate-like &gamma;&delta; T effectors performing potent immune surveillance against tumors. The constitutive expression of NKG2A identifies a subset of V&delta;2 T cells licensed with an intrinsic hyper-responsiveness against cancer. Indeed, the transcriptomic profiles of NKG2A+&nbsp;and NKG2A-&nbsp;cells characterize two distinct &quot;intralineages&quot; of V&delta;2 T lymphocytes that appear early during development, keep their phenotypes, and show self-renewal capabilities in adult life. The hyper-responsiveness of NKG2A+&nbsp;V&delta;2 T cells is counterbalanced by the inhibitory signaling delivered by human leukocyte antigen E (HLA-E) expressed on malignant cells as a tumor-escape mechanism. However, either masking or knocking out NKG2A restores the capacity of V&delta;2 T cells to exert the highest effector functions even against HLA-E+&nbsp;tumors. This is highly relevant in the clinic, as the different degrees of engagement of the NKG2A-HLA-E checkpoint in hepatocellular carcinoma, glioblastoma, and non-small cell lung cancer directly impact patients&#39; overall survival. These findings open avenues for developing combined cellular and immunologic anticancer therapies.</p>