Prognostic indicators of persistent carotid intima-media thickness increase in postpartum period in a population of normotensive women with gestational diabetes mellitus

<p><strong>OBJECTIVE: </strong>The association between gestational diabetes mellitus (GDM) and common carotid artery (CCA)-intima media thickness (IMT) is still controversial. In the present study, we aimed to compare the CCA-IMT measured in GDM women to that obtained in healthy pregnant women in the third trimester of pregnancy. Secondly, we investigated the main independent predictors of persistent CCA-IMT increase (defined as CCA-IMT &ge;0.6 mm) in postpartum period in GDM women.</p> <p><strong>STUDY DESIGN: </strong>30 consecutive GDM women and 30 healthy pregnant women matched for anagraphic age (34.1&plusmn;4.5 vs 32.8 &plusmn; 4.2 yrs, p=0.25), ethnicity (caucasian 56.7 vs 63.3%, p=0.59), gestational age (36.2&plusmn; 1.7 vs 36.5 &plusmn; 1.6 weeks, p=0.48) and cardiovascular risk factors were examined in this prospective case-control study. All women underwent obstetric visit, blood tests, conventional transthoracic echocardiography implemented with two-dimensional speckle tracking echocardiography analysis of left ventricular and left atrial myocardial strain parameters and carotid ultrasound examination at two time points: 36-38 weeks&rsquo; gestation and 6-10 weeks after delivery.</p> <p><strong>RESULTS: </strong>At 36.2&plusmn;1.7 weeks of gestation, CCA-IMT was significantly increased in GDM women than controls (0.81&plusmn;0.11 vs 0.55 &plusmn; 0.12, p &lt;0.001). Twelve GDM women (40% of the total) were found with persistent CCA-IMT increase (0.76&plusmn;0.14 mm) in postpartum period (8.2&plusmn;2.2 weeks), whereas the remaining 18 (60% of the total) showed a normalization in CCA-IMT (0.56&plusmn;0.1 mm). At multivariate logistic regression analysis, third trimester body mass index (BMI) (OR 1.78, 95%CI 1.24-2.54, p = 0.01), glycosylated hemoglobin (HbA1C) (OR 1.51, 95%CI 1.13-1.89, p = 0.03) and neutrophil-to-lymphocyte ratio (NLR) (OR 1.68, 95%CI 1.25-4.65, p = 0.02) resulted to be independently associated with persistent CCA-IMT increase in postpartum period in GDM women. A BMI &ge;29.2 Kg/m², an HbA1C &ge;37.5 mmol/mol and a NLR &ge;5.5 were the best cut-off values for identifying GDM women with persistent CCA-IMT increase in postpartum period.</p> <p><strong>CONCLUSIONS: </strong>GDM is associated with increased CCA-IMT during pregnancy. This increase may be persistent in postpartum period in GDM women with obesity, uncontrolled diabetes and increased inflammatory markers.</p>