Multi-scale simulations for optimizing cancer treatment

<p>The dataset comprises the output of several simulations of a model of tumor growth with different parameter values (10.1101/2021.12.17.473136). The model is a multi-scale agent-based model of a tumor spheroid that is treated with periodic pulses of the cytokine tumor necrosis factor (TNF). The multi-scale model&nbsp;simulates processes including i) the diffusion, uptake, and secretion of molecular entities such as oxygen, or TNF; ii) the mechanical interaction between cells; and iii) cellular processes including cell life cycle, cell death models, signal transduction.</p> <p>The multi-scale model was implemented and simulated using&nbsp;the PhysiBoSS&nbsp;framework (Letort et al. 2019). The dataset corresponds to 425 different simulations launched and automatically tagged as Interesting/Non-Interesting based on the effect of the parameters on the simulation (see README file). Each simulation&nbsp;was tagged by them with the following parameters (in that order):</p> <ul> <li>oxygen_necrotic, oxygen_critical</li> <li>oxygen_no_proliferation</li> <li>oxygen_reference</li> <li>initial_uptake_rate</li> <li>protein_threshold</li> <li>secretion_rate</li> <li>oxygen_concentration</li> <li>tnf_concentration</li> </ul> <p>Details on how these files are built can be found in the <strong>Biological Use Case</strong> output format file (<a href="https://zenodo.org/record/3921049">https://zenodo.org/record/3921049</a>).&nbsp;</p>