Lipidomic data of the kidney cortex from diabetic mice fed MUFA-HFD and SFA-HFD

<p><span>In diabetic patients, </span><span>dyslipidemia </span><span>frequently contributes to organ damage such as </span><span>diabetic kidney disease (DKD). DKD is associated with excessive renal deposition of triacylglycerol (TAG) in lipid droplets (LD). Yet, it is unclear whether LDs play a protective or damaging role and how this might be influenced by dietary patterns. By using a diabetes mouse model, we find here that high-fat diet enriched in the unsaturated oleic acid (OA) caused more lipid storage in LDs in renal proximal tubular cells (PTC) but less tubular damage than a corresponding butter diet with the saturated palmitic acid (PA). In order to study the changes in the lipidome, we performed shotgun lipidomics on the kidney cortex of these mice.</span></p>