Dataset related to the manuscript: "Migraine in Patients Undergoing PFO Closure: Characterization of a Platelet-associated Pathophysiological Mechanism. The LEARNER Study."

<p>Association between migraine and patent foramen ovale (PFO) has been documented. We aimed to investigate platelet activation, prothrombotic phenotype and oxidative stress status of migraineurs with PFO on 100mg/die aspirin, before and 6-months after PFO closure. Data show that, before PFO closure, expression of the classical platelet activation markers is comparable in patients and aspirin-treated-healthy subjects. Conversely, MHA-PFO patients display an increased prothrombotic phenotype (higher Tissue Factorpos -platelets and -microvesicles and thrombin generationeng potential), sustained by an altered oxidative stress status. This phenotype, which is more controlled by P2Y12-blockade than by aspirin, reverted after PFO closure together with a complete migraine remission</p>