Serial Crystallography with Multi-stage Merging oi 1000's of Images

<p>In the associated&nbsp;paper we discuss&nbsp;the issues involved in improving the sensitivity of both approaches to clustering, using, as an example, 999&nbsp; 5&nbsp;degree&nbsp;wedges from lysozyme in four iso-forms:</p> <p>&nbsp; NAG:&nbsp; native with N-acetylglucosamine (NAG) soaked in,<br> &nbsp; benzamadine: native with benzamadine soaked in,<br> &nbsp; benzamadine plus NAG: native with both NAG and benzamadine soaked in.<br> &nbsp; Native:&nbsp; no ligands</p> <p>Although the cell parameters are changed sufficiently to allow recognition of the NAG soak,&nbsp;it is difficult to filter the benzamadine soak simply on the basis of cell parameter changes, suggesting the desirability of switching from cell-based clustering to reflection-based clustering as early in the process as possible.&nbsp;</p> <p>The data is this dataset consists of a bzipped&nbsp;HKL structure factor tarball&nbsp;and a bzipped&nbsp;cluster data files from the four forms tarball.</p>