Supplementary data for article "Reduced B-cell antigenicity of Omicron lowers host serologic response"

<p>This repository contains five&nbsp;supplementary data files for the research&nbsp;article &quot;<strong>Reduced B-cell antigenicity of Omicron lowers host serologic response</strong>&quot;.&nbsp;For more information, please refer to the article preprint&nbsp;https://doi.org/10.1101/2022.02.15.480546 and upcoming article at Cell Reports.</p> <p>&nbsp;</p> <ol> <li><strong>Table_hCoV229E.xlsx:</strong>&nbsp;list of hCoV229E RBD sequences, with associated isolate and collection date identifiers, and ScanNet antigenicity score for reproducing&nbsp;<strong>Figure 3A</strong>. Aligned sequences and templates are also provided.</li> <li><strong>table_artificial_variants.csv</strong>: List of&nbsp;artificial RBD sequences generated by an evolutionary-based sequence generative model&nbsp;for reproducing&nbsp;<strong>Figure 3B</strong>,&nbsp;<strong>Supplementary Figure S6H</strong>.</li> <li><strong>MSA_RBD.fasta:</strong> Multiple Sequence Alignment of RBD sequences and sample weights used for training the sequence generative model used in&nbsp;<strong>Figure 3B</strong>,&nbsp;<strong>Supplementary Figures S2C, S6</strong>.</li> <li><strong>table_antibody_hit_rate_RBD.csv</strong>: Empirical epitope distribution for the RBD, as determined from the Protein Data Bank and&nbsp;raw data for&nbsp;<strong>Supplementary Figure&nbsp;S1</strong>).</li> <li><strong>RBD_virtual_DMS.xlsx</strong>: virtual Deep Mutational Scan performed with ScanNet and the sequence generative model shown in&nbsp;<strong>Supplementary Figure S2</strong>.</li> </ol> <p>&nbsp;</p> <p>&nbsp;</p>