Dynamic Covalent Michael Acceptors to Penetrate Cells: Thiol-Mediated Uptake with Tetrel-Centered Exchange Cascades, Assisted by Halogen-Bonding Switche

<p>Original data</p> <p>1.&nbsp; &nbsp; &nbsp; Synthesis and Characterization</p> <p>Compounds <strong>7</strong>, <strong>9</strong>, <strong>10</strong>, <strong>11</strong>, <strong>13</strong>, <strong>14</strong>, <strong>16</strong>, <strong>33</strong>, <strong>34</strong>, <strong>36</strong></p> <ul> <li>Lab Book Page; ¹H and ¹³C NMR; IR; HRMS</li> </ul> <p>Compound <strong>10 </strong>Stability Test</p> <ul> <li>Lab Book Page</li> <li>UV-Vis Absorption Spectra of <strong>10</strong> and <strong>41</strong> in PBS</li> <li>UV- Vis Absorption Spectra of <strong>10</strong> in Buffer After 72 h</li> <li>Kinetics 10 h in PBS; and in AMPSO Buffer</li> </ul> <p>Compound <strong>22</strong></p> <ul> <li>Lab Book Page</li> </ul> <p>Compounds <strong>47</strong>, <strong>48</strong>, <strong>53</strong>, <strong>55</strong>, <strong>56</strong></p> <ul> <li>Lab Book Pages; ¹H and ¹³C NMR; IR</li> </ul> <p>2.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Automated High-Content High-Throughput Screening</p> <ul> <li>Lab Book Pages and Data</li> </ul> <p>2.1. &nbsp;&nbsp; Inhibitor Screening with OPS Reporter</p> <p>2.2.&nbsp; &nbsp; Cellular Uptake of MAC Reporters</p> <p>2.3. &nbsp;&nbsp; Inhibitor Screening with MAC and CTO Reporters</p> <p>3.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Protein Uptake</p> <p>3.1. Preparation and Cellular Uptake of Streptavidin Complexes</p> <ul> <li>Lab Book Page and Data</li> </ul>