Human SAN model 2024 supplementary animations.

<p>This repository is associated with the manuscript: "<em>Computational investigation of structural (fibrosis) and functional (I_CaL and I_Na) causes of arrhythmogenesis in the human 3D sino-atrial node",&nbsp;</em>by Sanjay R Kharche^*, Galina Yu Mironova, Andrew Atkinson, and Donald G Welsh^*. This repository contains the animations referred to in the above manuscript. A description of the file names, figure labels, and draft figure legends is provided below.</p> <p>1) File name in repository: S1_supplementVideo1Control3D.gif</p> <p>Figure label: Figure S1.</p> <p>Draft figure legend: Animation of 3D SAN control activation sequence in the border (left) and no border (right) cases.</p> <p>&nbsp;</p> <p>2) File name in repository: S3_pacingInducedMacro2D_Supplement.gif</p> <p>Figure label: Figure S3.</p> <p>Draft figure legend:&nbsp;Animation of pacing induced macro re-entry, SEP block, and altered activation sequence in the 2D model under s_Na = 0.6 and s_Ca = 0.8 conditions. See Figure 7 and main manuscript for details.</p> <p>&nbsp;</p> <p>3) File name in repository: S4_supplementToFig6_sna0.8_sca0.8.gif</p> <p>Figure label: Figure S4.</p> <p>Draft figure legend: In relation to main manuscript Figure 6, animation of complex wave propagation under s_Na = s_Ca = 0.8 conditions. SEP block, macro-re-entry, as well as 2:1 propagation can be observed.</p> <p>&nbsp;</p> <p>4) File name in repository: S6_run1dir1_9_1_1_2DmacroAndAtrialSupplement.gif</p> <p>Figure label: Figure S6.</p> <p>Draft figure legend:&nbsp;Animation of pacing induced macro-reentry, SEP block, and altered activation sequence in the 2D model under s_Na = s_Ca = 1 and 10% fibrosis conditions. See Figure 11 and main manuscript for details.</p> <p>&nbsp;</p> <p>5) File name in repository: S7_run3dir1_9_1_1_2DmicroAndComplexSupplement.gif</p> <p>Figure label: Figure S7.</p> <p>Draft figure legend: Animation of pacing induced micro re-entry, SEP block, and altered activation sequence in the 2D model under s_Na = s_Ca = 1 and 10% fibrosis conditions. See Figure 12 and main manuscript for details.</p> <p>&nbsp;</p> <p>6) File name in repository: S8_nopacingMacroreentryCedar0.80.8HSANb1.gif</p> <p>Figure label: Figure S8.</p> <p>Draft figure legend: Macro re-entry in the 3D non pacing with border model. s_Na = s_Ca = 0.8. See <strong>Figure 14</strong> in main manuscript.</p> <p>&nbsp;</p> <p>7) File name in repository: S9_HumanSAN_0.8_0.8_nonPacingCedar_Border1.gif</p> <p>Figure label: Figure S9.</p> <p>Draft figure legend: Atrial (complex) re-entry in the 3D model with s_Na = s_Ca = 0.8, no pacing and 10% fibrosis. See Figure 14 in main MS.</p>