Data underpinning "Coupling between cerebral blood flow and cerebral blood volume: Contributions of different vascular compartments"

<p>The data in this archive was acquired to investigate the&nbsp;coupling between cerebral blood flow and cerebral blood volume across different vascular compartments. These&nbsp;results&nbsp;will form the basis of a forthcoming publication.&nbsp;Please reference this dataset (version v1.1.0)&nbsp;if you use it in your work. Wesolowski R, Blockley NP, Driver ID, Francis ST, Gowland PA.&nbsp;Data underpinning &quot;Coupling between cerebral blood flow and cerebral blood volume: Contributions of different vascular compartments&quot;. Zenodo 2018. doi:&nbsp;10.5281/zenodo.1411018.&nbsp;</p> <p>This dataset contains measurements of the haemodynamic responses of different compartments to a visual stimulus (8Hz red LED goggles, 19.2s ON, 40.8s OFF). Time course data are cycle averaged for the following haemodynamic properties;</p> <ol> <li>Arterial cerebral blood volume (CBVa) measured using Look-Locker Flow-sensitive Alternating Inversion Recovery (LL-FAIR) sensitised to CBVa.</li> <li>Cerebral blood flow (CBF) measured using Look-Locker Flow-sensitive Alternating Inversion Recovery (LL-FAIR) sensitised to CBF.</li> <li>Total cerebral blood volume (CBVtot) measured using bolus injections of a Gadolinium based contrast agent combined with&nbsp;T2* weighed gradient echo EPI.</li> </ol> <p>In addition, weighted mean and standard deviation of the&nbsp;changes in these parameters are presented using time windows of&nbsp;9.6&ndash;19.2s and 40.8&ndash;60s for ON and OFF, respectively. Weighting is performed with respect to the number of voxels present in each of the subjects regions of interest.</p> <p>Time course data were extracted from two different regions of interest;</p> <ol> <li>ROI_CBF: defined using&nbsp;a CBF localiser</li> <li>ROI_COMMON: defined using the overlap of CBF, CBV_a and CBV_tot localisers</li> </ol> <p>Furthermore, the transit times for CBF and CBVa were estimated for an average stimulus cycle and mean values extracted using&nbsp;time windows of&nbsp;9.6&ndash;19.2s and 40.8&ndash;60s for ON and OFF, respectively. These data were extracted from ROI_CBF.</p> <p>Changes</p> <p>- Addition of propagation of uncertainty for CBVv and the Grubb constants alpha_tot and alpha_a.</p> <p>&nbsp;</p>