Fig. 4 Ecology and phylogeny influence biosynthetic potential. a A in The antimicrobial potential from insect microbiomes of Streptomyces

Fig. 4 Ecology and phylogeny influence biosynthetic potential. a A core-genome phylogeny shows evolutionarily distinct lineages of Streptomyces associate with insects (subset shown, see Supplementary Figure 2). BGC similarity to known BGCs highlights the biosynthetic diversity of insect microbiome strains. b Source invariant (blue) and sub-clade invariant (red) BGC families suggest BGC presence is influenced by both source and phylogeny. LC/MS metabolomics revealed MFs that are unique to c source and d phylogeny. e PCA of the metabolomes identified an outlier strain and f MFs that contribute to its uniqueness, including cyphomycin