PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity

<p><strong>Introduction</strong></p> <p>These are the&nbsp;<em>Summary Level-data</em>&nbsp;as presented in:</p> <p>&quot;PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity&quot;.&nbsp;<em>Nature Communications&nbsp;</em>volume&nbsp;9, Article&nbsp;number:&nbsp;2904&nbsp;(2018) doi: 10.1038/s41467-018-04766-9&nbsp;</p> <p>If you use these data please cite the corresponding manuscript, which can be downloaded here:&nbsp;https://www.nature.com/articles/s41467-018-04766-9.&nbsp;When you have any questions or comments regarding this study or these files, please contact me via:</p> <p>Jessica van Setten, PhD&nbsp;|&nbsp;<em>Department of Cardiology, University Medical Center Utrecht, Utrecht University</em>&nbsp;|&nbsp;j.vansetten [at] umcutrecht [dot] nl</p> <p>&nbsp;</p> <p><strong>Files and description</strong></p> <p>The file&nbsp;PR_interval_July2018_summary_results.txt is&nbsp;gzipped and contains the PR interval GWAS meta-analysis summary results of 92,000 European samples. The imputation reference panel used for most studies&nbsp;was HapMap2 (please note: hg18, build36).&nbsp;</p> <ul> <li><em>SNP</em>&nbsp;- variantID (rsID).</li> <li><em>CHR</em>&nbsp;- chromosome numbers [1-22 and X].</li> <li><em>POS</em>&nbsp;- base pair position, hg18&nbsp;/ build36.</li> <li><em>CODED_ALLELE</em>&nbsp;- coded allele,&nbsp;<em>i.e.</em>&nbsp;the effect allele, as represented (and harmonized) across cohorts. Note that this is not necessarily the minor allele.</li> <li><em>NON_CODED_ALLELE</em>&nbsp;- the other allele,&nbsp;<em>i.e.</em>&nbsp;the non-effect allele.</li> <li><em>CODED_ALLELE_FREQ</em>&nbsp;- coded allele frequency,&nbsp;<em>i.e.</em>&nbsp;the effect allele frequency. Note that this is not necessarily the minor allele frequency.</li> <li><em>BETA_FIXED</em>&nbsp;- beta from the fixed-effects model.</li> <li><em>SE_FIXED&nbsp;</em>- standard error from the fixed-effects model.</li> <li><em>P_FIXED &nbsp;</em>- P-value&nbsp;from the fixed-effects model.</li> </ul>