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Investigating the effect of cochlear synaptopathy on envelope following responses using a model of the auditory nerve

Dataset containing the recorded and simulated data reported in the manuscript "Investigating the effect of cochlear synaptopathy on envelope following responses using a model of the auditory nerve" published in the Journal of the Association for Research in Otolaryngology, JARO (<a href="https://doi.org/10.1007/s10162-019-00721-7">https://doi.org/10.1007/s10162-019-00721-7</a>): <ol> <li>RECORDED Envelope Following Responses (EFR) in normal-hearing (NH) threshold and hearing-impaired (HI) human listeners using deeply (m = 85%) and shallowly (m = 25%) modulated sinusoidally amplitude modulated (SAM) tones.</li> <li>SIMULATED EFRs using the auditory nerve (AN) model by Zilany et al. (2009, 2014).</li> </ol> Files content and structure: Recorded EFRs Fig. 2: <ul> <li>fig2__recorded_efr.csv:                       EFR recordings as a function of stimulus level (EFR magnitude-level functions) for the NH and HI listeners using two modulation depths.</li> </ul> The file containing the recorded EFR data have the following columns: <ul> <li>lvl:                             Stimulation level</li> <li>m85_ok:                    EFR magnitude (dB re to 1 µV) using m = 85%. Significant responses (F-test = 1)</li> <li>m85_ko:                    EFR magnitude (dB re to 1 µV) using m = 85%. Non-significant responses (F-test = 0)</li> <li>m85_bkg:                  Estimated background noise magnitude (dB re to 1 µV) for the recordings when m = 85%</li> <li>m25_ok:                    EFR magnitude (dB re to 1 µV) using m = 25%. Significant responses (F-test = 1)</li> <li>m25_ko:                    EFR magnitude (dB re to 1 µV) using m = 25%. Non-significant responses (F-test = 0)</li> <li>m25_bkg:                  Estimated background noise magnitude (dB re to 1 µV) for the recordings when m = 25% </li> <li>subj:                          Listener id</li> <li>hearing:                     Hearing group (nh | hi) of the listener</li> </ul> Simulated EFRs: Files with the simulation results summing across frequency and SR fiber type Fig. 4: <ul> <li>fig4a__simul_efr__nh_23ohc_13ihc__no_cs.csv:                        Simulated EFR magnitude-level function for the NH threshold listeners (average) assuming 2/3 of OHC loss and 1/3 of IHC loss (Fig. 4a).</li> <li>fig4b__simul_efr__nh_slp_thres_all_ohc__no_cs.csv:               Simulated EFR magnitude-level function for the NH threshold listeners (average) assuming sloping threshold at extended high frequencies (EHF) and all of OHC loss (Fig. 4b).</li> <li>fig4c__simul_efr__nh_slp_thres_all_ihc__no_cs.csv:                Simulated EFR magnitude-level function for the NH threshold listeners (average) assuming sloping threshold at extended high frequencies (EHF) and all of IHC loss (Fig. 4c).</li> <li>fig4d__simul_efr__hi_23ohc_13ihc__no_cs.csv:                        Simulated EFR magnitude-level function for the HI listeners (average) assuming 2/3 of OHC loss and 1/3 of IHC loss (Fig. 4d).</li> <li>fig4e__simul_efr__hi_all_ohc__no_cs.csv:                                Simulated EFR magnitude-level function for the HI threshold listeners (average) assuming all of OHC loss (Fig. 4e).</li> <li>fig4f__simul_efr__hi_all_ihc__no_cs.csv:                Simulated EFR magnitude-level function for the HI threshold listeners (average) assuming all of IHC loss (Fig. 4f).</li> <li>fig4g__simul_efr__hi_slp_thres_23ohc_13ihc__no_cs.csv:                        Simulated EFR magnitude-level function for the HI listeners (average) assuming sloping threshold at EHF and 2/3 of OHC loss and 1/3 of IHC loss (Fig. 4d).</li> <li>fig4h__simul_efr__hi_slp_thres_all_ohc__no_cs.csv:                                Simulated EFR magnitude-level function for the HI threshold listeners (average) assuming sloping threshold at EHF and all of OHC loss (Fig. 4e).</li> <li>fig4i__simul_efr__hi_slp_thres_all_ihc__no_cs.csv:                Simulated EFR magnitude-level function for the HI threshold listeners (average) assuming sloping threshold at EHF and and all of IHC loss (Fig. 4f).</li> </ul>   Fig. 5: <ul> <li>fig5a__simul_efr__nh__cs_ms_ls_100p.csv:                               Simulated EFR magnitude-level function for the NH threshold listeners (average) assuming cochlear synaptopathy (CS) of a 100% of loss of only medium- and low-spontaneous rate (SR) AN fibers (Fig. 5a).</li> <li>fig5b__simul_efr__nh09_cs__approx.csv:             Simulated EFR magnitude-level function to approximate the data for the NH threshold listener NH09 including CS (Fig. 5b).</li> <li>fig5c__simul_efr__hi04_cs__approx.csv:   Simulated EFR magnitude-level function to approximate the data for the HI listener HI04 including CS (Fig. 5c).</li> </ul>   Fig. 6: Files with the simulation results for the NH threshold listener in different characteristic frequency (CF) bands and SR fiber types <ul> <li>fig6__simul_efr__nh_cf_band_analys__no_cs__m12.mat:           Simulated EFR magnitude-level function for the NH using a SAM tone with m = 12%.</li> <li>fig6__simul_efr__nh_cf_band_analys__no_cs__m25.mat:           Simulated EFR magnitude-level function for the NH using a SAM tone with m = 25%.</li> <li>fig6__simul_efr__nh_cf_band_analys__no_cs__m50.mat:           Simulated EFR magnitude-level function for the NH using a SAM tone with m = 50%.</li> <li>fig6__simul_efr__nh_cf_band_analys__no_cs__m85.mat:           Simulated EFR magnitude-level function for the NH using a SAM tone with m = 85%.</li> <li>fig6__simul_efr__nh_cf_band_analys__no_cs__m100.mat:         Simulated EFR magnitude-level function for the NH using a SAM tone with m = 100%.</li> </ul>   Fig. 7: <ul> <li>fig7a__simul_efr__bw_analys__32oct_[20, 40, 60, 80, 100]p.csv:                               Simulated EFR magnitude-level function for the NH threshold listeners assuming CS of a bandwidth (BW) of 3/2-octave for a loss of AN fibers ranging from 20% to 100% (Fig. 7a).</li> <li>fig7b__simul_efr__bw_analys__1oct_[20, 40, 60, 80, 100]p.csv:             Simulated EFR magnitude-level function for the NH threshold listeners assuming CS of a bandwidth (BW) of 1-octave for a loss of AN fibers ranging from 20% to 100% (Fig. 7b).</li> <li>fig7c__simul_efr__bw_analys__13oct_[20, 40, 60, 80, 100]p.csv: Simulated EFR magnitude-level function for the NH threshold listeners assuming CS of a bandwidth (BW) of 1/3-octave for a loss of AN fibers ranging from 20% to 100% (Fig. 7c).</li> </ul>   -----------------------------------------------------------------------------------------------------------------------------------------------------------------   The structure of the .csv files that contain the EFR simulations is: <ul> <li>lvl:                          Stimulation level</li> <li>mgn_mxxx:            Simulated EFR magnitude (a.u. in dB) for each modulation depth (100%, 85%, 50%, 25% and 12%)</li> <li>bkg_mxxx:             Estimate of the background noise floor (a.u. in dB) for each modulation depth. </li> <li>ftest_mxxx:            Result of the F-test statistical test (0 or 1) for each modulation depth.</li> </ul>   The structure of the .mat files that contain the EFR simulations is: <ul> <li>exper_type:           Name of the simulated experiment</li> <li>species:                 Species used in the AN model (in this study is always 2: human)</li> <li>species_age:         (Not used in this work). Age of the animal when species is 4: mouse</li> <li>modulation:            Modulation depth of the SAM tone used in the simulation (100%, 85%, 50%, 25% or 12%)</li> <li>f_on:                      Center frequency of the on-frequency band (2000 Hz)</li> <li>f_off_hf:                 Center frequency of the first off-frequency band (3000 Hz)</li> <li>f_off_vhf:               Center frequency of the second off-frequency band (7000 Hz) </li> <li>f_off_uvhf:             Center frequency of the third off-frequency band (12000 Hz)</li> <li>lvl_vect:                 Stimulus level vector (from 5 to 100 dB SPL, in steps of 5 dB)</li> <li>simul_efr               Structure with the simulated data <ul> <li>The data structure contains many fields which are matricies of size 3x20. The columns are the 20 stimulus levels defined in lvl_vect, and the first row is the simulated EFR, the second row is the estimates background noise floor in the simulation, and the third row is the output of the F-test statistics.</li> <li>The structure fields can be divided in 4 groups: <ul> <li>ihc_           Responses from the IHC (not shown in the paper)</li> <li>an_hs_      Responses from the High-SR fibers in the AN</li> <li>an_ms_     Responses from the Medium-SR fibers in the AN</li> <li>an_ls_       Responses from the Low-SR fibers in the AN</li> </ul> </li> <li>Each group has 5 responses corresponding to the on-frequency band (_on) and the three off-frequency bands (_off_hf, _off_vhf, _off_uvhf); and the sum across frequencies (_across_f)</li> </ul> </li> </ul>

ShareScore

44/100

Overall dataset sharing score

Score breakdown

These five areas show where the dataset supports — or may limit — practical reuse.

Stewardship: 8
Harmonization: 4
Access: 20
Reuse readiness: 8
Engagement: 4

Topics

cochlear synaptopathy "hidden" hearing loss envelope following responses auditory steady-state responses auditory nerve modeling